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Integration of Cryo-EM Model Building Software in Scipion

M. Martínez, A. Jiménez-Moreno, D. Maluenda, E. Ramírez-Aportela, R. Melero, A. Cuervo, P. Conesa, L. Del Caño, YC. Fonseca, R. Sánchez-García, D. Strelak, JJ. Conesa, E. Fernández-Giménez, F. de Isidro, COS. Sorzano, JM. Carazo, R. Marabini

. 2020 ; 60 (5) : 2533-2540. [pub] 20200211

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21020543

Advances in cryo-electron microscopy (cryo-EM) have made it possible to obtain structures of large biological macromolecules at near-atomic resolution. This "resolution revolution" has encouraged the use and development of modeling tools able to produce high-quality atomic models from cryo-EM density maps. Unfortunately, many practical problems appear when combining different packages in the same processing workflow, which make difficult the use of these tools by non-experts and, therefore, reduce their utility. We present here a major extension of the image processing framework Scipion that provides inter-package integration in the model building area and full tracking of the complete workflow, from image processing to structure validation.

Citace poskytuje Crossref.org

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