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Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity

M. Awan, I. Buriak, R. Fleck, B. Fuller, A. Goltsev, J. Kerby, M. Lowdell, P. Mericka, A. Petrenko, Y. Petrenko, O. Rogulska, A. Stolzing, GN. Stacey

. 2020 ; 15 (3) : 1463-1491. [pub] 20200428

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc21020732
E-resources Online Full text

NLK PubMed Central from 2015 to 1 year ago
ProQuest Central from 2018-01-01 to 2020-11-30
Health & Medicine (ProQuest) from 2018-01-01 to 2020-11-30

Links

PubMed 32342730
DOI 10.2217/rme-2019-0145
Knihovny.cz E-resources

Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.

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$a Buriak, Iryna $u Institute for Problems of Cryobiology & Cryomedicine, National Academy of Sciences of Ukraine, Pereyaslavska 23, 61016, Kharkiv
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