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Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry
F. D'Ascenzo, S. Gili, M. Bertaina, M. Iannaccone, VL. Cammann, D. Di Vece, K. Kato, A. Saglietto, KA. Szawan, AH. Frangieh, B. Boffini, M. Annaratone, A. Sarcon, RA. Levinson, J. Franke, LC. Napp, M. Jaguszewski, M. Noutsias, T. Münzel, M....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
31863563
DOI
10.1002/ejhf.1698
Knihovny.cz E-zdroje
- MeSH
- Aspirin terapeutické užití MeSH
- cévní mozková příhoda MeSH
- infarkt myokardu MeSH
- inhibitory agregace trombocytů terapeutické užití MeSH
- lidé MeSH
- recidiva MeSH
- registrace MeSH
- srdeční selhání MeSH
- takotsubo kardiomyopatie * farmakoterapie epidemiologie MeSH
- tendenční skóre MeSH
- tranzitorní ischemická ataka MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
AIMS: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). METHODS AND RESULTS: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting. CONCLUSION: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
1st Department of Cardiology Medical University of Gdansk Gdansk Poland
Center for Cardiology Cardiology 1 University Medical Center Mainz Mainz Germany
Center for Molecular Cardiology Schlieren Campus University of Zurich Zurich Switzerland
Centro Cardiologico Monzino IRCCS Milan Italy
Clinic for Cardiology and Pneumology Georg August University Goettingen Goettingen Germany
Department of Cardiology and Angiology Hannover Medical School Hannover Germany
Department of Cardiology and Cardiac Imaging Center University Hospital of Rangueil Toulouse France
Department of Cardiology Charité Campus Rudolf Virchow Berlin Germany
Department of Cardiology Heidelberg University Hospital Heidelberg Germany
Department of Cardiology John Radcliffe Hospital Oxford University Hospitals Oxford UK
Department of Cardiology Kantonsspital Frauenfeld Frauenfeld Switzerland
Department of Cardiology Kantonsspital Lucerne Lucerne Switzerland
Department of Cardiology Kantonsspital Winterthur Winterthur Switzerland
Department of Cardiology Kings College Hospital Kings Health Partners London UK
Department of Cardiology Leiden University Medical Centre Leiden The Netherlands
Department of Cardiology Medical University of Warsaw Warsaw Poland
Department of Cardiology University Heart Center University Hospital Zurich Zurich Switzerland
Department of Cardiology University Hospital Basel Basel Switzerland
Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany
Department of Internal Medicine 2 Cardiology University of Ulm Medical Center Ulm Germany
Department of Internal Medicine 3 Heart Center University of Cologne Cologne Germany
Department of Internal Medicine B University Medicine Greifswald Greifswald Germany
Department of Internal Medicine Cardiology Heart Center Leipzig University Hospital Leipzig Germany
Department of Mathematical Sciences Politecnico di Torino Turin Italy
Department of Medicine College of Medicine University of Florida Gainesville FL USA
Department of Medico Surgical Sciences and Biotechnologies Sapienza University of Rome Latina Italy
Deutsches Herzzentrum München Technische Universität München Munich Germany
Division of Biological Sciences University of California San Diego San Diego CA USA
Division of Cardiology 'Antonio Cardarelli' Hospital Naples Italy
Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA
DZHK partner site Greifswald Greifswald Germany
DZHK partner site Hamburg Kiel Luebeck Hamburg Germany
DZHK partner site Heidelberg Mannheim Mannheim Germany
DZHK partner site Munich Heart Alliance Munich Germany
Fondazione Policlinico Universitario A Gemelli IRCCS Università Cattolica del Sacro Cuore Rome Italy
Heart and Vascular Centre Bad Bevensen Bad Bevensen Germany
Heart Center Turku University Hospital and University of Turku Turku Finland
Heart Department University Hospital 'San Giovanni di Dio e Ruggi d'Aragona' Salerno Italy
Intensive Coronary Care Unit Moscow City Hospital 1 named after N Pirogov Moscow Russia
Internal Medicine Cardiology Angiology and Pneumology Magdeburg University Magdeburg Germany
Klinik für Innere Medizin 3 Universitätsklinikum des Saarlandes Homburg Germany
Krankenhaus Maria Hilf Medizinische Klinik Stadtlohn Germany
Royal Brompton and Harefield Hospitals Trust and Imperial College London UK
Structural Interventional Cardiology University Hospital Careggi Florence Italy
TJ Health Partners Heart and Vascular Glasgow KY USA
University Hospital for Internal Medicine 3 Medical University Innsbruck Innsbruck Austria
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- $a Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry / $c F. D'Ascenzo, S. Gili, M. Bertaina, M. Iannaccone, VL. Cammann, D. Di Vece, K. Kato, A. Saglietto, KA. Szawan, AH. Frangieh, B. Boffini, M. Annaratone, A. Sarcon, RA. Levinson, J. Franke, LC. Napp, M. Jaguszewski, M. Noutsias, T. Münzel, M. Knorr, S. Heiner, HA. Katus, C. Burgdorf, H. Schunkert, H. Thiele, J. Bauersachs, C. Tschöpe, BM. Pieske, L. Rajan, G. Michels, R. Pfister, A. Cuneo, C. Jacobshagen, G. Hasenfuß, M. Karakas, W. Koenig, W. Rottbauer, SM. Said, RC. Braun-Dullaeus, A. Banning, F. Cuculi, R. Kobza, TA. Fischer, T. Vasankari, KEJ. Airaksinen, G. Opolski, R. Dworakowski, P. MacCarthy, C. Kaiser, S. Osswald, L. Galiuto, F. Crea, W. Dichtl, WM. Franz, K. Empen, SB. Felix, C. Delmas, O. Lairez, I. El-Battrawy, I. Akin, M. Borggrefe, JD. Horowitz, M. Kozel, P. Tousek, P. Widimský, E. Gilyarova, A. Shilova, M. Gilyarov, G. Biondi-Zoccai, DE. Winchester, C. Ukena, M. Neuhaus, JJ. Bax, A. Prasad, C. Di Mario, M. Böhm, M. Gasparini, F. Ruschitzka, E. Bossone, R. Citro, M. Rinaldi, GM. De Ferrari, T. Lüscher, JR. Ghadri, C. Templin
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- $a AIMS: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). METHODS AND RESULTS: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting. CONCLUSION: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
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