Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

HPV, protein p16 and squamous cell carcinoma of the oral cavity

J. Blahak, J. Zelinka, J. Gumulec, C. Machacek, Z. Danek, O. Bulik

. 2020 ; 164 (3) : 292-299. [pub] 20190617

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21021190

BACKGROUND: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. METHODS: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. RESULTS: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). CONCLUSIONS: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21021190
003      
CZ-PrNML
005      
20210908164856.0
007      
ta
008      
210806s2020 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2019.026 $2 doi
035    __
$a (PubMed)31219104
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Blahák, Jiří, $d 1986- $7 xx0195644 $u Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
245    10
$a HPV, protein p16 and squamous cell carcinoma of the oral cavity / $c J. Blahak, J. Zelinka, J. Gumulec, C. Machacek, Z. Danek, O. Bulik
504    __
$a Literatura
520    9_
$a BACKGROUND: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. METHODS: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. RESULTS: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). CONCLUSIONS: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.
650    _2
$a senioři $7 D000368
650    _2
$a spinocelulární karcinom $x diagnóza $x patofyziologie $7 D002294
650    _2
$a inhibitor p16 cyklin-dependentní kinasy $x metabolismus $7 D019941
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nádory úst $x diagnóza $x patofyziologie $7 D009062
650    _2
$a infekce papilomavirem $x diagnóza $x patofyziologie $7 D030361
650    _2
$a prognóza $7 D011379
650    _2
$a míra přežití $7 D015996
655    _2
$a časopisecké články $7 D016428
700    1_
$a Zelinka, Jiří $7 xx0231273 $u Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
700    1_
$a Gumulec, Jaromír, $d 1963- $7 xx0054104 $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Macháček, Ctirad $7 xx0154019 $u Department of Pathology, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
700    1_
$a Daněk, Zdeněk $7 xx0191609 $u Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
700    1_
$a Bulik, Oliver $7 xx0107917 $u Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Masaryk University, Brno and University Hospital Brno, Brno, Czech Republic
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia $x 1213-8118 $g Roč. 164, č. 3 (2020), s. 292-299
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31219104 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y p $z 0
990    __
$a 20210806 $b ABA008
991    __
$a 20210903151723 $b ABA008
999    __
$a ok $b bmc $g 1694797 $s 1141643
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 164 $c 3 $d 292-299 $e 20190617 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20210806

Find record

Citation metrics

Archiving options