Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia - Czech national study

K. Stranska, K. Plevova, H. Skuhrova Francova, H. Skabrahova, M. von Jagwitz-Biegnitz, L. Radova, A. Panovska, S. Hrobkova, Y. Brychtova, R. Urbanova, L. Smolej, M. Simkovic, J. Zuchnicka, L. Mohammadova, M. Spacek, J. Mayer, S. Pospisilova, M. Doubek

. 2020 ; 164 (4) : 425-434. [pub] 20190926

Language English Country Czech Republic

Document type Comparative Study, Journal Article

Persistent link   https://www.medvik.cz/link/bmc21023715

AIMS: This is a nation-wide survey of chronic lymphocytic leukemia (CLL) patients at six large hematology centers in the Czech Republic. The aim was to identify specific populations, social, and health characteristics of CLL subgroups divided according to the immunogenetic features of their B cell receptors (BCRs) and clonality. PATIENTS AND METHODS: Questionnaires directed to specific health, social, and environmental conditions were collected in a cohort of 573 CLL patients. For these patients, immunoglobulin heavy chain gene rearrangements were also analyzed in order to gain information about their clonality, IGHV mutational status, and the presence of stereotyped BCRs. Data extracted from the questionnaires were analyzed statistically in the context of immunogenetic features of the cohort. RESULTS: There were no statistically significant differences in the data collected in the survey between patients with mutated and patients with unmutated IGHV. However, patients with oligoclonal CLL reported health conditions such as hypercholesterolemia, hypertension, herpes simplex, tumors, and also, separately, CLL in 1st degree relatives, more often than their monoclonal counterparts. In patients with stereotyped BCRs, we found more frequent alcohol consumption and gastric infections in subset #1 cases and frequent cholecystectomies and familial CLL in subset #2 cases. CONCLUSION: To the best of our knowledge, this study is the first to investigate CLL immunogenetic features and clonality in the context of epidemiological data. We reported statistically significant associations suggesting the influence of certain health and social conditions on a number of clonal populations expanding in CLL and also on characteristic BCR features, especially stereotypy.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21023715
003      
CZ-PrNML
005      
20211104134118.0
007      
ta
008      
211005s2020 xr f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2019.046 $2 doi
035    __
$a (PubMed)31558845
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Stránská, Kamila $7 xx0231087 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
245    10
$a Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia - Czech national study / $c K. Stranska, K. Plevova, H. Skuhrova Francova, H. Skabrahova, M. von Jagwitz-Biegnitz, L. Radova, A. Panovska, S. Hrobkova, Y. Brychtova, R. Urbanova, L. Smolej, M. Simkovic, J. Zuchnicka, L. Mohammadova, M. Spacek, J. Mayer, S. Pospisilova, M. Doubek
504    __
$a Literatura
520    9_
$a AIMS: This is a nation-wide survey of chronic lymphocytic leukemia (CLL) patients at six large hematology centers in the Czech Republic. The aim was to identify specific populations, social, and health characteristics of CLL subgroups divided according to the immunogenetic features of their B cell receptors (BCRs) and clonality. PATIENTS AND METHODS: Questionnaires directed to specific health, social, and environmental conditions were collected in a cohort of 573 CLL patients. For these patients, immunoglobulin heavy chain gene rearrangements were also analyzed in order to gain information about their clonality, IGHV mutational status, and the presence of stereotyped BCRs. Data extracted from the questionnaires were analyzed statistically in the context of immunogenetic features of the cohort. RESULTS: There were no statistically significant differences in the data collected in the survey between patients with mutated and patients with unmutated IGHV. However, patients with oligoclonal CLL reported health conditions such as hypercholesterolemia, hypertension, herpes simplex, tumors, and also, separately, CLL in 1st degree relatives, more often than their monoclonal counterparts. In patients with stereotyped BCRs, we found more frequent alcohol consumption and gastric infections in subset #1 cases and frequent cholecystectomies and familial CLL in subset #2 cases. CONCLUSION: To the best of our knowledge, this study is the first to investigate CLL immunogenetic features and clonality in the context of epidemiological data. We reported statistically significant associations suggesting the influence of certain health and social conditions on a number of clonal populations expanding in CLL and also on characteristic BCR features, especially stereotypy.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    12
$a biologické faktory $7 D001685
650    _2
$a kohortové studie $7 D015331
650    _2
$a ženské pohlaví $7 D005260
650    12
$a genetická variace $7 D014644
650    _2
$a genotyp $7 D005838
650    _2
$a genetika člověka $7 D000074705
650    _2
$a lidé $7 D006801
650    12
$a imunogenetika $7 D007125
650    _2
$a chronická lymfatická leukemie $x epidemiologie $x genetika $x imunologie $7 D015451
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a receptory antigenů B-buněk $x genetika $7 D011947
650    _2
$a rizikové faktory $7 D012307
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Plevová, Karla $7 xx0158852 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Francová, Hana $7 xx0101487 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Škabrahová, Hana $7 xx0265039 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Jagwitz-Biegnitz, Magdalena von $7 _AN111840 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Radová, Lenka $7 xx0092752 $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Panovská, Anna $7 xx0137441 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Hrobková, Stanislava $7 xx0223964 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Brychtová, Yvona $7 xx0105542 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Urbanova, Renata $u Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic
700    1_
$a Smolej, Lukáš $7 xx0101489 $u 4th Department of Internal Medicine - Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
700    1_
$a Šimkovič, Martin, $d 1982- $7 xx0117538 $u 4th Department of Internal Medicine - Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
700    1_
$a Zuchnická, Jana $7 xx0227525 $u Department of Hematooncology, University Hospital Ostrava, Czech Republic
700    1_
$a Mohammadová, Lekaá, $d 1980- $7 xx0232153 $u Department of Hematology and Oncology, University Hospital Pilsen, Czech Republic
700    1_
$a Špaček, Martin $7 xx0063837 $u 1st Department of Medicine - Department of Hematology, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
700    1_
$a Mayer, Jiří, $d 1960- $7 nlk20000083651 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Pospíšilová, Šárka, $d 1969- $7 xx0101843 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Doubek, Michael, $d 1972- $7 mzk2004217554 $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia $x 1213-8118 $g Roč. 164, č. 4 (2020), s. 425-434
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31558845 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y p $z 0
990    __
$a 20211005 $b ABA008
991    __
$a 20211007125719 $b ABA008
999    __
$a ok $b bmc $g 1718903 $s 1144209
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 164 $c 4 $d 425-434 $e 20190926 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20211005

Find record

Citation metrics

Archiving options