Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

P. Nakhaei, R. Margiana, DO. Bokov, WK. Abdelbasset, MA. Jadidi Kouhbanani, RS. Varma, F. Marofi, M. Jarahian, N. Beheshtkhoo

. 2021 ; 9 (-) : 705886. [pub] 20210909

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21023974

Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21023974
003      
CZ-PrNML
005      
20211013134105.0
007      
ta
008      
211006s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fbioe.2021.705886 $2 doi
035    __
$a (PubMed)34568298
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Nakhaei, Pooria $u School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
245    10
$a Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol / $c P. Nakhaei, R. Margiana, DO. Bokov, WK. Abdelbasset, MA. Jadidi Kouhbanani, RS. Varma, F. Marofi, M. Jarahian, N. Beheshtkhoo
520    9_
$a Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol.
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Margiana, Ria $u Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia $u Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia $u Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia
700    1_
$a Bokov, Dmitry O $u Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russia $u Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russia
700    1_
$a Abdelbasset, Walid Kamal $u Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia $u Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt
700    1_
$a Jadidi Kouhbanani, Mohammad Amin $u Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czechia
700    1_
$a Varma, Rajender S $u Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czechia
700    1_
$a Marofi, Faroogh $u Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
700    1_
$a Jarahian, Mostafa $u Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany
700    1_
$a Beheshtkhoo, Nasrin $u Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czechia
773    0_
$w MED00188064 $t Frontiers in bioengineering and biotechnology $x 2296-4185 $g Roč. 9, č. - (2021), s. 705886
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34568298 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20211006 $b ABA008
991    __
$a 20211013134102 $b ABA008
999    __
$a ind $b bmc $g 1708149 $s 1144468
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 9 $c - $d 705886 $e 20210909 $i 2296-4185 $m Frontiers in bioengineering and biotechnology $n Front Bioeng Biotechnol $x MED00188064
LZP    __
$a Pubmed-20211006

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace