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Biologicals in childhood severe asthma: the European PERMEABLE survey on the status quo
E. Santos-Valente, H. Buntrock-Döpke, R. Abou Taam, S. Arasi, A. Bakirtas, J. Lozano Blasco, K. Bønnelykke, M. Craiu, R. Cutrera, A. Deschildre, B. Elnazir, L. Fleming, U. Frey, M. Gappa, A. Nieto García, K. Skamstrup Hansen, L. Hanssens, K....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2015
PubMed Central
od 2015
Europe PubMed Central
od 2015
Open Access Digital Library
od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2015
- Publikační typ
- časopisecké články MeSH
Introduction: Severe asthma is a rare disease in children, for which three biologicals, anti-immunoglobulin E, anti-interleukin-5 and anti-IL4RA antibodies, are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed to investigate the status quo and identify open questions in biological therapy of childhood asthma across Europe. Methods: Structured interviews regarding experience with biologicals, regulations on access to the different treatment options, drug selection, therapy success and discontinuation of therapy were performed. Content analysis was used to analyse data. Results: We interviewed 37 experts from 25 European countries and Turkey and found a considerable range in the number of children treated with biologicals per centre. All participating countries provide public access to at least one biological. Most countries allow different medical disciplines to prescribe biologicals to children with asthma, and only a few restrict therapy to specialised centres. We observed significant variation in the time point at which treatment success is assessed, in therapy duration and in the success rate of discontinuation. Most participating centres intend to apply a personalised medicine approach in the future to match patients a priori to available biologicals. Conclusion: Substantial differences exist in the management of childhood severe asthma across Europe, and the need for further studies on biomarkers supporting selection of biologicals, on criteria to assess therapy response and on how/when to end therapy in stable patients is evident.
Allergy Dept 2nd Pediatric Clinic National and Kapodistrian University of Athens Athens Greece
Allergy Unit 1st Dept of Pediatrics Faculty of Medicine Semmelweis University Budapest Hungary
Children's Health Ireland at Tallaght University Hospital Dublin Ireland
Datadesk Limited Regensburg Germany
Dept of Clinical Immunology and Allergology University Teaching Hospital in Martin Martin Slovakia
Dept of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden
Dept of Otorhinolaryngology Amsterdam UMC University of Amsterdam Amsterdam the Netherlands
Dept of Otorhinolaryngology Tergooi Hospitals Hilversum the Netherlands
Dept of Paediatric Pulmonology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands
Dept of Paediatrics Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia
Dept of Paediatrics Respiratory Medicine and Allergy Mater Dei Hospital Malta
Dept of Pediatric Pneumology Allergology and Neonatology Hannover Medical School Hannover Germany
Dept of Pediatrics Antwerp University Hospital Edegem Belgium
Dept of Pediatrics Herlev and Gentofte Hospital University Hospital Copenhagen Denmark
Dept of Respiratory Medicine Amsterdam UMC University of Amsterdam Amsterdam the Netherlands
EPIUnit Instituto de Saúde Pública Universidade do Porto Porto Portugal
Evangelisches Krankenhaus Düsseldorf Children's Hospital Düsseldorf Germany
German Center for Lung Research DZL Airway Center North Hannover Germany
Grigore Alexandrescu Emergency Hospital for Children Bucharest Romania
Mother and Child Health Institute of Serbia Belgrade Serbia
Paediatric Respiratory Medicine Royal Brompton and Harefield NHS Foundation Trust London UK
Respiratory Paediatrics National Heart and Lung Institute Imperial College London London UK
Royal Hospital for Children and Young People Edinburgh UK
Sachs' Children and Youth Hospital Södersjukhuset Stockholm Sweden
Service de pneumologie pédiatrique AP HP Hôpital Necker Enfants Malades Paris France
Serviço de Imunoalergologia Centro Hospitalar Universitário de São João Porto Portugal
Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland
Trinity College Dublin Ireland
University Children's Hospital Basel University of Basel Basel Switzerland
University Children's Hospital Bern Inselspital University of Bern Switzerland
Citace poskytuje Crossref.org
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- $a Biologicals in childhood severe asthma: the European PERMEABLE survey on the status quo / $c E. Santos-Valente, H. Buntrock-Döpke, R. Abou Taam, S. Arasi, A. Bakirtas, J. Lozano Blasco, K. Bønnelykke, M. Craiu, R. Cutrera, A. Deschildre, B. Elnazir, L. Fleming, U. Frey, M. Gappa, A. Nieto García, K. Skamstrup Hansen, L. Hanssens, K. Jahnz-Rozyk, M. Jesenak, S. Kerzel, MV. Kopp, GH. Koppelman, U. Krivec, KA. MacLeod, M. Mäkelä, E. Melén, G. Mezei, A. Moeller, A. Moreira, P. Pohunek, P. Minić, NWP. Rutjes, P. Sammut, N. Schwerk, Z. Szépfalusi, M. Turkalj, I. Tzotcheva, A. Ulmeanu, S. Verhulst, P. Xepapadaki, J. Niggel, S. Vijverberg, AH. Maitland-van der Zee, U. Potočnik, SM. Reinartz, CM. van Drunen, M. Kabesch
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- $a Introduction: Severe asthma is a rare disease in children, for which three biologicals, anti-immunoglobulin E, anti-interleukin-5 and anti-IL4RA antibodies, are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed to investigate the status quo and identify open questions in biological therapy of childhood asthma across Europe. Methods: Structured interviews regarding experience with biologicals, regulations on access to the different treatment options, drug selection, therapy success and discontinuation of therapy were performed. Content analysis was used to analyse data. Results: We interviewed 37 experts from 25 European countries and Turkey and found a considerable range in the number of children treated with biologicals per centre. All participating countries provide public access to at least one biological. Most countries allow different medical disciplines to prescribe biologicals to children with asthma, and only a few restrict therapy to specialised centres. We observed significant variation in the time point at which treatment success is assessed, in therapy duration and in the success rate of discontinuation. Most participating centres intend to apply a personalised medicine approach in the future to match patients a priori to available biologicals. Conclusion: Substantial differences exist in the management of childhood severe asthma across Europe, and the need for further studies on biomarkers supporting selection of biologicals, on criteria to assess therapy response and on how/when to end therapy in stable patients is evident.
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