-
Je něco špatně v tomto záznamu ?
Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017
B. Kohlmaier, NA. Schweintzger, MG. Sagmeister, V. Švendová, DS. Kohlfürst, A. Sonnleitner, M. Leitner, A. Berghold, E. Schmiedberger, F. Fazekas, A. Pichler, J. Rejc-Marko, D. Růžek, L. Dufková, D. Čejková, P. Husa, M. Pýchová, L. Krbková, V....
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
Land Steiermark (Office of the regional government of Styria, department of health, care and science, unit science and research, Austria)
NV19-05-00457
Czech Ministry of Health
P3-0296
Slovenian Research Agency
NLK
Directory of Open Access Journals
od 2013
PubMed Central
od 2013
Europe PubMed Central
od 2013
ProQuest Central
od 2013-01-01
Open Access Digital Library
od 2013-01-01
Open Access Digital Library
od 2013-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2013
- Publikační typ
- časopisecké články MeSH
Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.
Department of General Paediatrics Medical University of Graz 8036 Graz Austria
Department of Infectious Diseases Hospital Ceske Budejovice 370 01 Ceske Budejovice Czech Republic
Department of Infectious Diseases Lithuanian University of Health Sciences 44307 Kaunas Lithuania
Department of Infectious Diseases University Medical Centre Ljubljana 1000 Ljubljana Slovenia
Department of Neurology Medical University of Graz 8036 Graz Austria
Deptartment of Infectious Diseases University Hospital Brno 625 00 Brno Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21024478
- 003
- CZ-PrNML
- 005
- 20230808105249.0
- 007
- ta
- 008
- 211006s2021 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/microorganisms9071420 $2 doi
- 035 __
- $a (PubMed)34209373
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Kohlmaier, Benno $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 245 10
- $a Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017 / $c B. Kohlmaier, NA. Schweintzger, MG. Sagmeister, V. Švendová, DS. Kohlfürst, A. Sonnleitner, M. Leitner, A. Berghold, E. Schmiedberger, F. Fazekas, A. Pichler, J. Rejc-Marko, D. Růžek, L. Dufková, D. Čejková, P. Husa, M. Pýchová, L. Krbková, V. Chmelík, V. Štruncová, D. Zavadska, G. Karelis, A. Mickiene, J. Zajkowska, P. Bogovič, F. Strle, W. Zenz, . The Eu-Tick-Bo Study Group
- 520 9_
- $a Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Schweintzger, Nina A $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Sagmeister, Manfred G $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Švendová, Vendula $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria $u Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Kohlfürst, Daniela S $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Sonnleitner, Astrid $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Leitner, Manuel $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Berghold, Andrea $u Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Schmiedberger, Erich $u Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Fazekas, Franz $u Department of Neurology, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Pichler, Alexander $u Department of Neurology, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a Rejc-Marko, Jana $u Department of Infectious Diseases and Febrile Conditions, University Clinical Center Maribor, 2000 Maribor, Slovenia
- 700 1_
- $a Růžek, Daniel, $u Biology Centre of the Czech Academy of Sciences, Institute of Parasitology, Ceske Budejovice, 370 01 Ceske Budejovice, Czech Republic $u Veterinary Research Institute, 621 00 Brno, Czech Republic $d 1981- $7 stk2008441707
- 700 1_
- $a Dufková, Lucie $u Veterinary Research Institute, 621 00 Brno, Czech Republic
- 700 1_
- $a Čejková, Darina $u Veterinary Research Institute, 621 00 Brno, Czech Republic
- 700 1_
- $a Husa, Petr $u Deptartment of Infectious Diseases, University Hospital Brno, 625 00 Brno, Czech Republic $u Department of Infectious Diseases, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic
- 700 1_
- $a Pýchová, Martina $u Deptartment of Infectious Diseases, University Hospital Brno, 625 00 Brno, Czech Republic $u Department of Infectious Diseases, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic
- 700 1_
- $a Krbková, Lenka $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, 613 00 Brno, Czech Republic
- 700 1_
- $a Chmelík, Václav $u Department of Infectious Diseases, Hospital Ceske Budejovice, 370 01 Ceske Budejovice, Czech Republic
- 700 1_
- $a Štruncová, Věra $u Department of Infectious Disease and Travel Medicine, University Hospital Plzeň and Faculty of Medicine in Pilsen, Charles University, 306 05 Plzeň, Czech Republic
- 700 1_
- $a Zavadska, Dace $u Department of Paediatrics, Children Clinical University Hospital, Riga Stradins University, LV-1004 Riga, Latvia
- 700 1_
- $a Karelis, Guntis $u Department of Neurology and Neurosurgery, Riga East University Hospital, Riga Stradins University, LV-1004 Riga, Latvia
- 700 1_
- $a Mickiene, Aukse $u Department of Infectious Diseases, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
- 700 1_
- $a Zajkowska, Joanna $u Department of Infectious Diseases and Neuroinfections, Medical University Bialystok, 15-089 Bialystok, Poland
- 700 1_
- $a Bogovič, Petra $u Department of Infectious Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
- 700 1_
- $a Strle, Franc $u Department of Infectious Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
- 700 1_
- $a Zenz, Werner $u Department of General Paediatrics, Medical University of Graz, 8036 Graz, Austria
- 700 1_
- $a The Eu-Tick-Bo Study Group,
- 773 0_
- $w MED00198767 $t Microorganisms $x 2076-2607 $g Roč. 9, č. 7 (2021)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34209373 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20211006 $b ABA008
- 991 __
- $a 20230808105246 $b ABA008
- 999 __
- $a ind $b bmc $g 1708340 $s 1144975
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 9 $c 7 $e 20210630 $i 2076-2607 $m Microorganisms $n Microorganisms $x MED00198767
- GRA __
- $p Land Steiermark (Office of the regional government of Styria, department of health, care and science, unit science and research, Austria)
- GRA __
- $a NV19-05-00457 $p Czech Ministry of Health
- GRA __
- $a P3-0296 $p Slovenian Research Agency
- LZP __
- $a Pubmed-20211006
