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Mortality in Children Treated With Maintenance Peritoneal Dialysis: Findings From the International Pediatric Peritoneal Dialysis Network Registry
S. Ploos van Amstel, M. Noordzij, D. Borzych-Duzalka, NC. Chesnaye, H. Xu, L. Rees, IS. Ha, ZL. Antonio, N. Hooman, W. Wong, K. Vondrak, YC. Yap, H. Patel, M. Szczepanska, S. Testa, M. Galanti, JA. Kari, C. Samaille, SA. Bakkaloglu, WM. Lai, LF....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
- MeSH
- časové faktory MeSH
- chronické selhání ledvin mortalita terapie MeSH
- dítě MeSH
- lidé MeSH
- míra přežití trendy MeSH
- mladiství MeSH
- následné studie MeSH
- peritoneální dialýza metody MeSH
- předškolní dítě MeSH
- příčina smrti trendy MeSH
- prospektivní studie MeSH
- registrace MeSH
- věkové faktory MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Asie MeSH
- Evropa MeSH
- Severní Amerika MeSH
RATIONALE & OBJECTIVE: Research on pediatric kidney replacement therapy (KRT) has primarily focused on Europe and North America. In this study, we describe the mortality risk of children treated with maintenance peritoneal dialysis (MPD) in different parts of the world and characterize the associated demographic and macroeconomic factors. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Patients younger than 19 years at inclusion into the International Pediatric Peritoneal Dialysis Network registry, who initiated MPD between 1996 and 2017. EXPOSURE: Region as primary exposure (Asia, Western Europe, Eastern Europe, Latin America, North America, and Oceania). Other demographic, clinical, and macroeconomic (4 income groups based on gross national income) factors also were studied. OUTCOME: All-cause MPD mortality. ANALYTICAL APPROACH: Patients were observed for 3 years, and the mortality rates in different regions and income groups were calculated. Cause-specific hazards models with random effects were fit to calculate the proportional change in variance for factors that could explain variation in mortality rates. RESULTS: A total of 2,956 patients with a median age of 7.8 years at the start of KRT were included. After 3 years, the overall probability of death was 5%, ranging from 2% in North America to 9% in Eastern Europe. Mortality rates were higher in low-income countries than in high-income countries. Income category explained 50.1% of the variance in mortality risk between regions. Other explanatory factors included peritoneal dialysis modality at start (22.5%) and body mass index (11.1%). LIMITATIONS: The interpretation of interregional survival differences as found in this study may be hampered by selection bias. CONCLUSIONS: This study shows that the overall 3-year patient survival on pediatric MPD is high, and that country income is associated with patient survival.
Aliasghar Clinical Research Development Center Iran University of Medical Sciences Tehran Iran
Children's Hospital of Fudan University Shanghai People's Republic of China
Children's Mercy Kansas City MO
Department of Paediatrics Hospital Tunku Azizah Kuala Lumpur Malaysia
Department of Pediatric Nephrology National Kidney and Transplant Institute Quezon City Philippines
Department of Pediatric Nephrology School of Medicine Gazi University Ankara Turkey
Department of Pediatrics Nephrology and Hypertension Medical University of Gdansk Gdansk Poland
Fondazione Ospedale Maggiore Policlinico Milan Italy
Great Ormond Street Hospital London United Kingdom
Hospital Infantil de Nicaragua Manuel de Jesus Rivera Managua Nicaragua
Nationwide Children's Hospital Columbus OH
NRS Medical College and Hospital Kolkata India
Pediatrics Seoul National University Children's Hospital Seoul South Korea
Roberto del Río Hospital Santiago Chile
School of Medicine Johns Hopkins University Baltimore MD
Service de Néphrologie Pédiatrique Hôpital Jeanne De Flandre Lille France
Citace poskytuje Crossref.org
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- $a Ploos van Amstel, Sophie $u IPNA Global RRT Registry, Department of Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands
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- $a Mortality in Children Treated With Maintenance Peritoneal Dialysis: Findings From the International Pediatric Peritoneal Dialysis Network Registry / $c S. Ploos van Amstel, M. Noordzij, D. Borzych-Duzalka, NC. Chesnaye, H. Xu, L. Rees, IS. Ha, ZL. Antonio, N. Hooman, W. Wong, K. Vondrak, YC. Yap, H. Patel, M. Szczepanska, S. Testa, M. Galanti, JA. Kari, C. Samaille, SA. Bakkaloglu, WM. Lai, LF. Rojas, MS. Diaz, B. Basu, A. Neu, BA. Warady, KJ. Jager, F. Schaefer
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- $a RATIONALE & OBJECTIVE: Research on pediatric kidney replacement therapy (KRT) has primarily focused on Europe and North America. In this study, we describe the mortality risk of children treated with maintenance peritoneal dialysis (MPD) in different parts of the world and characterize the associated demographic and macroeconomic factors. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Patients younger than 19 years at inclusion into the International Pediatric Peritoneal Dialysis Network registry, who initiated MPD between 1996 and 2017. EXPOSURE: Region as primary exposure (Asia, Western Europe, Eastern Europe, Latin America, North America, and Oceania). Other demographic, clinical, and macroeconomic (4 income groups based on gross national income) factors also were studied. OUTCOME: All-cause MPD mortality. ANALYTICAL APPROACH: Patients were observed for 3 years, and the mortality rates in different regions and income groups were calculated. Cause-specific hazards models with random effects were fit to calculate the proportional change in variance for factors that could explain variation in mortality rates. RESULTS: A total of 2,956 patients with a median age of 7.8 years at the start of KRT were included. After 3 years, the overall probability of death was 5%, ranging from 2% in North America to 9% in Eastern Europe. Mortality rates were higher in low-income countries than in high-income countries. Income category explained 50.1% of the variance in mortality risk between regions. Other explanatory factors included peritoneal dialysis modality at start (22.5%) and body mass index (11.1%). LIMITATIONS: The interpretation of interregional survival differences as found in this study may be hampered by selection bias. CONCLUSIONS: This study shows that the overall 3-year patient survival on pediatric MPD is high, and that country income is associated with patient survival.
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