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The role of interictal discharges in ictogenesis - A dynamical perspective

J. Chvojka, J. Kudlacek, WC. Chang, O. Novak, F. Tomaska, J. Otahal, JGR. Jefferys, P. Jiruska

. 2021 ; 121 (Pt B) : 106591. [pub] 20191202

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21025204

Grantová podpora
NV17-28427A MZ0 CEP - Centrální evidence projektů

Interictal epileptiform discharge (IED) is a traditional hallmark of epileptic tissue that is generated by the synchronous activity of a population of neurons. Interictal epileptiform discharges represent a heterogeneous group of pathological activities that differ in shape, duration, spatiotemporal distribution, underlying cellular and network mechanisms, and their relationship to seizure genesis. The exact role of IEDs in epilepsy is still not well understood, and there remains a persistent dichotomy about the impact on IEDs on seizures. Proseizure, antiseizure, and no impact on ictogenesis have all been described in previous studies. In this article, we review the existing knowledge on the role of interictal discharges in seizure genesis, and we discuss how dynamical approaches to ictogenesis can explain the existing dichotomy about the multifaceted role of IEDs in ictogenesis. This article is part of the Special Issue "NEWroscience 2018".

Citace poskytuje Crossref.org

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$a Chvojka, Jan $u Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
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$a Interictal epileptiform discharge (IED) is a traditional hallmark of epileptic tissue that is generated by the synchronous activity of a population of neurons. Interictal epileptiform discharges represent a heterogeneous group of pathological activities that differ in shape, duration, spatiotemporal distribution, underlying cellular and network mechanisms, and their relationship to seizure genesis. The exact role of IEDs in epilepsy is still not well understood, and there remains a persistent dichotomy about the impact on IEDs on seizures. Proseizure, antiseizure, and no impact on ictogenesis have all been described in previous studies. In this article, we review the existing knowledge on the role of interictal discharges in seizure genesis, and we discuss how dynamical approaches to ictogenesis can explain the existing dichotomy about the multifaceted role of IEDs in ictogenesis. This article is part of the Special Issue "NEWroscience 2018".
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$a Kudlacek, Jan $u Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
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$a Chang, Wei-Chih $u Faculty of Veterinary Medicine and Neuroscience Center, University of Helsinki, Helsinki 00014, Finland
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$a Novak, Ondrej $u Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
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$a Tomaska, Filip $u Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
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$a Jiruska, Premysl $u Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: jiruskap@lfmotol.cuni.cz
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