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Emerging glyco-based strategies to steer immune responses
M. Anderluh, F. Berti, A. Bzducha-Wróbel, F. Chiodo, C. Colombo, F. Compostella, K. Durlik, X. Ferhati, R. Holmdahl, D. Jovanovic, W. Kaca, L. Lay, M. Marinovic-Cincovic, M. Marradi, M. Ozil, L. Polito, JJ. Reina-Martin, CA. Reis, R. Sackstein,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
NLK
Free Medical Journals
od 2005 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2005-01-01 do Před 1 rokem
Wiley Free Content
od 2005 do Před 1 rokem
PubMed
33752265
DOI
10.1111/febs.15830
Knihovny.cz E-zdroje
- MeSH
- autoimunita imunologie MeSH
- chimerické antigenní receptory imunologie MeSH
- lidé MeSH
- mezibuněčná komunikace imunologie MeSH
- nanočástice chemie MeSH
- polysacharidy chemie imunologie MeSH
- posttranslační úpravy proteinů MeSH
- T-lymfocyty imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Glycan structures are common posttranslational modifications of proteins, which serve multiple important structural roles (for instance in protein folding), but also are crucial participants in cell-cell communications and in the regulation of immune responses. Through the interaction with glycan-binding receptors, glycans are able to affect the activation status of antigen-presenting cells, leading either to induction of pro-inflammatory responses or to suppression of immunity and instigation of immune tolerance. This unique feature of glycans has attracted the interest and spurred collaborations of glyco-chemists and glyco-immunologists to develop glycan-based tools as potential therapeutic approaches in the fight against diseases such as cancer and autoimmune conditions. In this review, we highlight emerging advances in this field, and in particular, we discuss on how glycan-modified conjugates or glycoengineered cells can be employed as targeting devices to direct tumor antigens to lectin receptors on antigen-presenting cells, like dendritic cells. In addition, we address how glycan-based nanoparticles can act as delivery platforms to enhance immune responses. Finally, we discuss some of the latest developments in glycan-based therapies, including chimeric antigen receptor (CAR)-T cells to achieve targeting of tumor-associated glycan-specific epitopes, as well as the use of glycan moieties to suppress ongoing immune responses, especially in the context of autoimmunity.
Blood Transfusion Center of Slovenia Ljubljana Slovenia
Chair of Pharmaceutical Chemistry Faculty of Pharmacy University of Ljubljana Slovenia
Department of Biochemistry Faculty of Science Charles University Prague Czech Republic
Department of Biotechnology and Food Microbiology Warsaw University of Life Sciences SGGW Poland
Department of Chemistry 'Ugo Schiff' University of Florence Florence Italy
Department of Chemistry and CRC Materiali Polimerici University of Milan Italy
Department of Chemistry Faculty of Arts and Sciences Recep Tayyip Erdogan University Rize Turkey
Department of Medical Biotechnology and Translational Medicine University of Milan Italy
Department of Microbiology and Parasitology Jan Kochanowski University Kielce Poland
Department of Organic Chemistry Faculty of Sciences University of Malaga Spain
I3S Instituto de Investigação e Inovação em Saúde Universidade do Porto Portugal
National Research Council CNR SCITEC Milan Italy
Citace poskytuje Crossref.org
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