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Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view
C. Huart, CM. Philpott, A. Altundag, AW. Fjaeldstad, J. Frasnelli, S. Gane, JW. Hsieh, EH. Holbrook, I. Konstantinidis, BN. Landis, A. Macchi, CA. Mueller, S. Negoias, JM. Pinto, SC. Poletti, VR. Ramakrishnan, P. Rombaux, J. Vodicka, A....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed
33728824
DOI
10.1002/alr.22788
Knihovny.cz E-zdroje
- MeSH
- celosvětové zdraví MeSH
- čichová sliznice účinky léků virologie MeSH
- COVID-19 * komplikace patofyziologie MeSH
- hormony kůry nadledvin farmakologie MeSH
- lidé MeSH
- management farmakoterapie normy statistika a číselné údaje MeSH
- nežádoucí účinky léčiv diagnóza etiologie prevence a kontrola MeSH
- odhad potřeb MeSH
- poruchy čichu * farmakoterapie epidemiologie etiologie MeSH
- SARS-CoV-2 patogenita MeSH
- spontánní remise MeSH
- výzkumný projekt MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID-19-related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID-19-related olfactory dysfunction is high; and (3) corticosteroids have well-known potential adverse effects. We encourage randomized placebo-controlled trials investigating the efficacy of systemic steroids in this indication and strongly emphasize to initially consider smell training, which is supported by a robust evidence base and has no known side effects.
2nd Academic ORL Department Papageorgiou Hospital Aristotle University Thessaloniki Greece
Department of Anatomy Université du Québec à Trois Rivières Trois Rivières Quebec Canada
Department of Otorhinolaryngology Biruni University Istanbul Turkey
Department of Otorhinolaryngology Cliniques universitaires Saint Luc Brussels Belgium
Department of Otorhinolaryngology Inselspital University Hospital Bern Bern Switzerland
Department of Otorhinolaryngology Medical University of Vienna Vienna Austria
ENT clinic Asst Settelaghi University of Insubriae Varese Italy
Flavour Clinic Department of Otorhinolaryngology Regional Hospital West Jutland Holstebro Denmark
Flavour Institute Aarhus University Aarhus Denmark
Institute of Neuroscience Univeristé catholique de Louvain Brussels Belgium
Massachusetts Eye and Ear Harvard University Boston Massachusetts
Norwich Medical School University of East Anglia Norwich UK
Section of Otolaryngology Head and Neck Surgery The University of Chicago Chicago Illinois
Smell and Taste Clinic Department of Otorhinolaryngology TU Dresden Dresden Germany
The Norfolk Smell and Taste Clinic Norfolk and Waveney ENT Service Gorleston UK
Citace poskytuje Crossref.org
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