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Folding DNA into origami nanostructures enhances resistance to ionizing radiation

L. Sala, A. Zerolová, A. Rodriguez, D. Reimitz, M. Davídková, K. Ebel, I. Bald, J. Kočišek

. 2021 ; 13 (25) : 11197-11203. [pub] 2021Jul01

Language English Country Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21025485

We report experimental results on damage induced by ionizing radiation to DNA origami triangles which are commonly used prototypes for scaffolded DNA origami nanostructures. We demonstrate extreme stability of DNA origami upon irradiation, which is caused by (i) the multi-row design holding the shape of the origami even after severe damage to the scaffold DNA and (ii) the reduction of damage to the scaffold DNA due to the protective effect of the folded structure. With respect to damage induced by ionizing radiation, the protective effect of the structure is superior to that of a naturally paired DNA double helix. Present results allow estimating the stability of scaffolded DNA origami nanostructures in applications such as nanotechnology, pharmacy or in singulo molecular studies where they are exposed to ionizing radiation from natural and artificial sources. Additionally, possibilities are opened for scaffolded DNA use in the design of radiation-resistant and radio-sensitive materials.

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$a We report experimental results on damage induced by ionizing radiation to DNA origami triangles which are commonly used prototypes for scaffolded DNA origami nanostructures. We demonstrate extreme stability of DNA origami upon irradiation, which is caused by (i) the multi-row design holding the shape of the origami even after severe damage to the scaffold DNA and (ii) the reduction of damage to the scaffold DNA due to the protective effect of the folded structure. With respect to damage induced by ionizing radiation, the protective effect of the structure is superior to that of a naturally paired DNA double helix. Present results allow estimating the stability of scaffolded DNA origami nanostructures in applications such as nanotechnology, pharmacy or in singulo molecular studies where they are exposed to ionizing radiation from natural and artificial sources. Additionally, possibilities are opened for scaffolded DNA use in the design of radiation-resistant and radio-sensitive materials.
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$a Rodriguez, Alvaro $u J. Heyrovský Institute of Physical Chemistry of the CAS, Dolejškova 3, 18223 Prague, Czech Republic. jaroslav.kocisek@jh-inst.cas.cz
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$a Reimitz, Dan $u J. Heyrovský Institute of Physical Chemistry of the CAS, Dolejškova 3, 18223 Prague, Czech Republic. jaroslav.kocisek@jh-inst.cas.cz
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$a Davídková, Marie $u Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Na Truhlářce 39/64, 180 00 Prague, Czech Republic
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$a Ebel, Kenny $u Institute of Chemistry-Physical Chemistry, Universität Potsdam, Karl-Liebknecht-Straße 24-25, D-14476 Potsdam, Germany
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$a Bald, Ilko $u Institute of Chemistry-Physical Chemistry, Universität Potsdam, Karl-Liebknecht-Straße 24-25, D-14476 Potsdam, Germany
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$a Kočišek, Jaroslav $u J. Heyrovský Institute of Physical Chemistry of the CAS, Dolejškova 3, 18223 Prague, Czech Republic. jaroslav.kocisek@jh-inst.cas.cz
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