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Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening
J. Handl, D. Malinak, J. Capek, R. Andrys, E. Rousarova, M. Hauschke, L. Bruckova, P. Cesla, T. Rousar, K. Musilek
Chemical research in toxicology.
2021 ;
34 (3) :
699-703.
[pub] 20210210
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc21025964
- MeSH
- buněčné linie MeSH
- ledviny účinky léků metabolismus MeSH
- lidé MeSH
- molekulární struktura MeSH
- oximy aplikace a dávkování škodlivé účinky chemie MeSH
- reaktivátory cholinesterázy aplikace a dávkování škodlivé účinky chemie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole-pyridinium product.
Citace poskytuje Crossref.org
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- $a Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole-pyridinium product.
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