• Je něco špatně v tomto záznamu ?

How immune-cell fate and function are determined by metabolic pathway choice: The bioenergetics underlying the immune response

M. Hortová-Kohoutková, P. Lázničková, J. Frič

. 2021 ; 43 (2) : e2000067. [pub] 20201116

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026097

Grantová podpora
MAGNET: CZ.02.1.01/0.0/0.0/15_003/0000492 European Social Fund and European Regional Development Fund
CZ.02.1.01/0.0/0.0/16_019/0000868 ENOCH
NV18-06-00529 Ministry of Health of the Czech Republic

Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21026097
003      
CZ-PrNML
005      
20211026133219.0
007      
ta
008      
211013s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/bies.202000067 $2 doi
035    __
$a (PubMed)33191545
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hortová-Kohoutková, Marcela $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
245    10
$a How immune-cell fate and function are determined by metabolic pathway choice: The bioenergetics underlying the immune response / $c M. Hortová-Kohoutková, P. Lázničková, J. Frič
520    9_
$a Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.
650    _2
$a buněčná diferenciace $7 D002454
650    12
$a energetický metabolismus $7 D004734
650    _2
$a lidé $7 D006801
650    _2
$a imunitní systém $7 D007107
650    12
$a imunita $7 D007109
650    _2
$a metabolické sítě a dráhy $7 D053858
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Lázničková, Petra $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Frič, Jan $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic
773    0_
$w MED00000692 $t BioEssays : news and reviews in molecular, cellular and developmental biology $x 1521-1878 $g Roč. 43, č. 2 (2021), s. e2000067
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33191545 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211026133225 $b ABA008
999    __
$a ok $b bmc $g 1714954 $s 1146604
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 43 $c 2 $d e2000067 $e 20201116 $i 1521-1878 $m BioEssays $n Bioessays $x MED00000692
GRA    __
$a MAGNET: CZ.02.1.01/0.0/0.0/15_003/0000492 $p European Social Fund and European Regional Development Fund
GRA    __
$a CZ.02.1.01/0.0/0.0/16_019/0000868 $p ENOCH
GRA    __
$a NV18-06-00529 $p Ministry of Health of the Czech Republic
LZP    __
$a Pubmed-20211013

Najít záznam

Citační ukazatele

Možnosti archivace