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Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper
E. Jha, PK. Panda, P. Patel, P. Kumari, S. Mohanty, S. Parashar, R. Ahuja, SK. Verma, M. Suar
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
NLK
PubMed Central
od 2015 do Před 1 rokem
ProQuest Central
od 2006-06-01 do 2021-01-31
Health & Medicine (ProQuest)
od 2006-06-01 do 2021-01-31
PubMed
33501847
DOI
10.2217/nnm-2020-0395
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- antiinfekční látky * MeSH
- HCT116 buňky MeSH
- lidé MeSH
- Piper nigrum * MeSH
- superoxiddismutasa MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Aim: Fabrication of nanopepper (NP) for antibacterial application and elucidation of its molecular and cellular biocompatibility. Materials & methods: Synthesis of NP was achieved using a high-energy ball milling method. Following characterization, its antibacterial activity and cellular and molecular biocompatibility were evaluated in vitro by experimental and computational approaches. Results: A total of 15 h of milling pepper produced NP with a size of 44 ± 12 nm and zeta potential of -22 ± 12 mV. Bulk pepper and NP showed antibacterial activity and an LC50 of 1.9 μM and 2.1 μM in HCT116 colon cells. Components of pepper, piperine and β-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. Conclusion: NP exhibits significant antibacterial activity with cellular biocompatibility due to intrinsic atomic interaction. Aim: Fabrication of nanopepper (NP) for antibacterial application and elucidation of its molecular and cellular biocompatibility. Materials & methods: Synthesis of NP was achieved using a high-energy ball milling method. Following characterization, its antibacterial activity and cellular and molecular biocompatibility were evaluated in vitro by experimental and computational approaches. Results: A total of 15 h of milling pepper produced NP with a size of 44 ± 12 nm and zeta potential of -22 ± 12 mV. Bulk pepper and NP showed antibacterial activity and an LC50 of 1.9 μM and 2.1 μM in HCT116 colon cells. Components of pepper, piperine and β-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. Conclusion: NP exhibits significant antibacterial activity with cellular biocompatibility due to intrinsic atomic interaction.
Department of Physics and Astronomy Uppsala University Uppsala 75121 Sweden
Faculty of Science Masaryk University Brno 60300 Czech Republic
School of Applied Sciences KIIT University Bhubaneswar 751024 India
School of Biotechnology KIIT University Bhubaneswar 751024 India
Citace poskytuje Crossref.org
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