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The actin regulator profilin 1 is functionally associated with the mammalian centrosome
M. Nejedlá, A. Klebanovych, V. Sulimenko, T. Sulimenko, E. Dráberová, P. Dráber, R. Karlsson
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- Actins metabolism MeSH
- Caco-2 Cells MeSH
- Centrosome metabolism MeSH
- Formins metabolism MeSH
- Gene Knockout Techniques MeSH
- Humans MeSH
- Melanoma, Experimental metabolism pathology MeSH
- Microfilament Proteins metabolism MeSH
- Microtubules metabolism MeSH
- Mice MeSH
- Skin Neoplasms metabolism pathology MeSH
- Polymerization MeSH
- Profilins genetics metabolism MeSH
- Signal Transduction genetics MeSH
- Transfection MeSH
- Tubulin metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.
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- $a Klebanovych, Anastasiya $u Department of Biology of Cytoskeleton, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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