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The actin regulator profilin 1 is functionally associated with the mammalian centrosome

M. Nejedlá, A. Klebanovych, V. Sulimenko, T. Sulimenko, E. Dráberová, P. Dráber, R. Karlsson

. 2021 ; 4 (1) : . [pub] 20201112

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026419

Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.

Citace poskytuje Crossref.org

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$a Klebanovych, Anastasiya $u Department of Biology of Cytoskeleton, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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$a Sulimenko, Vadym $u Department of Biology of Cytoskeleton, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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$a Karlsson, Roger $u Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden roger.karlsson@su.se
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