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Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats
P. Mareš, J. Folbergrová, R. Haugvicová, H. Kubová
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- 2-Amino-5-phosphonovalerate analogs & derivatives MeSH
- Receptors, AMPA antagonists & inhibitors MeSH
- Benzodiazepines MeSH
- Quinoxalines MeSH
- Dizocilpine Maleate MeSH
- Homocysteine analogs & derivatives chemistry toxicity MeSH
- Rats, Wistar MeSH
- Receptors, N-Methyl-D-Aspartate antagonists & inhibitors MeSH
- Stereoisomerism MeSH
- Seizures chemically induced MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Mechanism of ictogenesis of D- and L-stereroisomers of homocysteic acid was studied in 12-day-old rats by means of antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. There was no qualitative difference between the two stereoisomers in generation of emprosthotonic (flexion) as well as generalized tonic-clonic seizures. Moderate differences were observed in the first, nonconvulsive effects of the two isomers. As generation of the two types of seizures is concerned, NMDA and AMPA participate in generalized tonic-clonic seizures whereas NMDA receptors play a dominant role in generation of flexion seizures.
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