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ADHD symptoms induced by prenatal methamphetamine exposure
A. Ochozková, L. Mihalčíková, A. Yamamotová, R. Šlamberová
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Attention Deficit Disorder with Hyperactivity chemically induced MeSH
- Hyperkinesis chemically induced MeSH
- Methamphetamine adverse effects MeSH
- Rats, Wistar MeSH
- Central Nervous System Stimulants adverse effects MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Methamphetamine is commonly used psychostimulant in the Czech Republic and is often abused by pregnant women. Methamphetamine may cause abnormalities in placenta and umbilical cord that results in hypoxia and malnutrition. ADHD is a mental disorder with a heterogeneous origin. The number of patients suffering from ADHD is growing. The pathophysiological mechanisms causing ADHD have not yet been clarified. There are very few rat models for ADHD and include genetic models, chemically induced models (ethanol, nicotine, PCBs, 6-hydroxydopamine lesion) or environmentally induced models (anoxia). The aim of the present study was to test prenatal methamphetamine exposure (5 mg/kg) as a potential novel animal model for ADHD. We found that adult male offspring prenatally exposed to methamphetamine presented hyperactivity while exploring novel environments. Together with cognition changes found in our previous studies, these might represent symptoms similar to those seen in ADHD. More experiments are planned to investigate our hypothesis.
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