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Endocrine risk factors for COVID-19 in context of aging
L. Máčová, M. Bičíková, R. Hampl
Language English Country Czech Republic
Document type Journal Article, Review
NLK
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PubMed Central
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from 2005-01-01
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- MeSH
- Adaptive Immunity MeSH
- COVID-19 immunology metabolism physiopathology virology MeSH
- Endocrine System immunology metabolism physiopathology virology MeSH
- Immunosenescence MeSH
- Host-Pathogen Interactions MeSH
- Humans MeSH
- Immunity, Innate MeSH
- Renin-Angiotensin System * MeSH
- SARS-CoV-2 immunology pathogenicity MeSH
- Aging immunology metabolism MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Aged people are the most susceptible group to COVID-19 infection. Immunosenescence characterized by impairment of immune function with inflamm-aging contributes to pathophysiological alterations, among which endocrine and metabolic diseases are not exception. Diabetes, obesity along with impairment of disorders of thyroid functions are the most frequent ones, the common feature of which is failure of immune system including autoimmune processes. In the minireview we discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes. Mentioned is also beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues. Particular attention is devoted to the role of ACE2 protein in the light of its intimate link with renin-angiotensin regulating system.
References provided by Crossref.org
Literatura
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