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Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes
A. Moore, MJ. Machiela, M. Machado, SS. Wang, E. Kane, SL. Slager, W. Zhou, M. Carrington, Q. Lan, RL. Milne, BM. Birmann, HO. Adami, D. Albanes, AA. Arslan, N. Becker, Y. Benavente, S. Bisanzi, P. Boffetta, PM. Bracci, P. Brennan, AR....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
HHSN268201100046C
NHLBI NIH HHS - United States
P30 ES000260
NIEHS NIH HHS - United States
U58 DP000807
NCCDPHP CDC HHS - United States
HHSN261201000034C
NCI NIH HHS - United States
R01 CA134674
NCI NIH HHS - United States
N01 PC067009
NCI NIH HHS - United States
HHSN268201100001I
NHLBI NIH HHS - United States
P30 CA016087
NCI NIH HHS - United States
HHSN261201000140C
NCI NIH HHS - United States
N01 PC067010
NCI NIH HHS - United States
R01 CA098122
NCI NIH HHS - United States
U01 HG007033
NHGRI NIH HHS - United States
P01 CA087969
NCI NIH HHS - United States
HHSN261201000035C
NCI NIH HHS - United States
R01 CA134958
NCI NIH HHS - United States
R21 CA165923
NCI NIH HHS - United States
HHSN268201100004I
NHLBI NIH HHS - United States
P30 CA086862
NCI NIH HHS - United States
U01 CA167552
NCI NIH HHS - United States
N01 PC067008
NCI NIH HHS - United States
HHSN268201100003C
WHI NIH HHS - United States
R01 CA148690
NCI NIH HHS - United States
R01 CA154643
NCI NIH HHS - United States
R01 CA062006
NCI NIH HHS - United States
N01 PC065064
NCI NIH HHS - United States
K08 CA134919
NCI NIH HHS - United States
UL1 TR000135
NCATS NIH HHS - United States
HHSN271201100004C
NIA NIH HHS - United States
R01 CA098661
NCI NIH HHS - United States
UM1 CA186107
NCI NIH HHS - United States
HHSN268201100002C
WHI NIH HHS - United States
P30 CA015083
NCI NIH HHS - United States
R01 CA092153
NCI NIH HHS - United States
ZIA CP010136
Intramural NIH HHS - United States
HHSN261201000035I
NCI NIH HHS - United States
P50 CA097274
NCI NIH HHS - United States
HHSN268201100003I
NHLBI NIH HHS - United States
R01 CA049449
NCI NIH HHS - United States
HHSN268201100002I
NHLBI NIH HHS - United States
R01 CA200703
NCI NIH HHS - United States
N01CO12400
NCI NIH HHS - United States
HHSN261200800001C
CCR NIH HHS - United States
U01 CA049449
NCI NIH HHS - United States
R01 CA149445
NCI NIH HHS - United States
HHSN261201000026C
NCI NIH HHS - United States
HHSN268201100001C
WHI NIH HHS - United States
HHSN268201100004C
WHI NIH HHS - United States
U01 CA118444
NCI NIH HHS - United States
HHSN261200800001E
NCI NIH HHS - United States
P30 CA042014
NCI NIH HHS - United States
- Publikační typ
- časopisecké články MeSH
Aim: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic variation. We sought to examine genome-wide homozygosity and NHL risk. Methods: We used data from eight genome-wide association studies of four common NHL subtypes: 3061 chronic lymphocytic leukemia (CLL), 3814 diffuse large B-cell lymphoma (DLBCL), 2784 follicular lymphoma (FL), and 808 marginal zone lymphoma (MZL) cases, as well as 9374 controls. We examined the effect of homozygous variation on risk by: (1) estimating the fraction of the autosome containing runs of homozygosity (FROH); (2) calculating an inbreeding coefficient derived from the correlation among uniting gametes (F3); and (3) examining specific autosomal regions containing ROH. For each, we calculated beta coefficients and standard errors using logistic regression and combined estimates across studies using random-effects meta-analysis. Results: We discovered positive associations between FROH and CLL (β = 21.1, SE = 4.41, P = 1.6 × 10-6) and FL (β = 11.4, SE = 5.82, P = 0.02) but not DLBCL (P = 1.0) or MZL (P = 0.91). For F3, we observed an association with CLL (β = 27.5, SE = 6.51, P = 2.4 × 10-5). We did not find evidence of associations with specific ROH, suggesting that the associations observed with FROH and F3 for CLL and FL risk were not driven by a single region of homozygosity. Conclusion: Our findings support the role of recessive genetic variation in the etiology of CLL and FL; additional research is needed to identify the specific loci associated with NHL risk.
Bill Lyons Informatics Centre UCL Cancer Institute University College London London WC1E 6DD UK
Cancer Control Research BC Cancer Agency Vancouver British Columbia V5Z1L3 Canada
Cancer Epidemiology Division Cancer Council Victoria Melbourne Victoria 3004 Australia
Cancer Epidemiology Unit University of Oxford Oxford OX3 7LF UK
Concord Clinical School University of Sydney Concord New South Wales 2139 Australia
Consortium for Biomedical Research in Epidemiology and Public Health Barcelona 08036 Spain
Department of Environmental Health Sciences Yale School of Public Health New Haven CT 06520 USA
Department of Epidemiology Brown University Providence RI 02903 USA
Department of Epidemiology Harvard T H Chan School of Public Health Boston MA 02115 USA
Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA
Department of Family Medicine and Public Health Sciences Wayne State University Detroit MI 48201 USA
Department of Health Sciences Research Mayo Clinic Rochester MN 55905 USA
Department of Health Sciences University of York York YO10 5DD UK
Department of Hematology Centre Léon Bérard Lyon 69008 France
Department of Hematology Hospices Civils de Lyon Pierre Benite Cedex 69495 France
Department of Hematology Université Lyon 1 Pierre Benite Cedex 69495 France
Department of Immunology Genetics and Pathology Uppsala University Uppsala 75105 Sweden
Department of Internal Medicine Mayo Clinic Rochester MN 55905 USA
Department of Medical and Surgical Sciences University of Bologna Bologna 41026 Italy
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm 17176 Sweden
Department of Medicine Memorial Sloan Kettering Cancer Center New York NY 10065 USA
Department of Medicine Solna Karolinska Institutet Stockholm 17176 Sweden
Department of Medicine Stanford University School of Medicine Stanford CA 94305 USA
Department of Obstetrics and Gynecology New York University School of Medicine New York NY 10016 USA
Department of Population Health New York University School of Medicine New York NY 10016 USA
Department of Population Science American Cancer Society Atlanta GA 30303 USA
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD 20892 USA
Division of Endocrinology Diabetes and Metabolism The Ohio State University Columbus OH 43210 USA
Division of Health Analytics City of Hope Beckman Research Institute Duarte CA 91010 USA
Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA 98117 USA
Genome Sciences Centre BC Cancer Agency Vancouver British Columbia V5Z1L3 Canada
Genomic Epidemiology Group German Cancer Research Center Heidelberg 69120 Germany
Hematology Center Karolinska University Hospital Stockholm 17176 Sweden
INSERM U1052 Cancer Research Center of Lyon Centre Léon Bérard Lyon 69008 France
INSERM U1052 Cancer Research Center of Lyon Lyon 1 University Pierre Bénite Cedex 69008 France
Institute for Risk Assessment Sciences Utrecht University Utrecht 3584 CG The Netherlands
International Agency for Research on Cancer Lyon 69372 France
Perlmutter Comprehensive Cancer Center NYU Langone Health New York NY 10016 USA
Ragon Institute of MGH Cambridge MA 02139 USA
Registre des Hémopathies Malignes de la Gironde Institut Bergonié Bordeaux Cedex 33076 France
School of Nursing Psychotherapy and Community Health Dublin City University Dublin 9 Ireland
School of Public Health Imperial College London London W2 1PG UK
Stony Brook Cancer Center Stony Brook University Stony Brook NY 11794 USA
Citace poskytuje Crossref.org
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- $a U01 HG007033 $p NHGRI NIH HHS $2 United States
- GRA __
- $a P01 CA087969 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN261201000035C $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA134958 $p NCI NIH HHS $2 United States
- GRA __
- $a R21 CA165923 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201100004I $p NHLBI NIH HHS $2 United States
- GRA __
- $a P30 CA086862 $p NCI NIH HHS $2 United States
- GRA __
- $a U01 CA167552 $p NCI NIH HHS $2 United States
- GRA __
- $a N01 PC067008 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201100003C $p WHI NIH HHS $2 United States
- GRA __
- $a R01 CA148690 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA154643 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA062006 $p NCI NIH HHS $2 United States
- GRA __
- $a N01 PC065064 $p NCI NIH HHS $2 United States
- GRA __
- $a K08 CA134919 $p NCI NIH HHS $2 United States
- GRA __
- $a UL1 TR000135 $p NCATS NIH HHS $2 United States
- GRA __
- $a HHSN271201100004C $p NIA NIH HHS $2 United States
- GRA __
- $a R01 CA098661 $p NCI NIH HHS $2 United States
- GRA __
- $a UM1 CA186107 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201100002C $p WHI NIH HHS $2 United States
- GRA __
- $a P30 CA015083 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA092153 $p NCI NIH HHS $2 United States
- GRA __
- $a ZIA CP010136 $p Intramural NIH HHS $2 United States
- GRA __
- $a HHSN261201000035I $p NCI NIH HHS $2 United States
- GRA __
- $a P50 CA097274 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201100003I $p NHLBI NIH HHS $2 United States
- GRA __
- $a R01 CA049449 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201100002I $p NHLBI NIH HHS $2 United States
- GRA __
- $a R01 CA200703 $p NCI NIH HHS $2 United States
- GRA __
- $a N01CO12400 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN261200800001C $p CCR NIH HHS $2 United States
- GRA __
- $a U01 CA049449 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA149445 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN261201000026C $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201100001C $p WHI NIH HHS $2 United States
- GRA __
- $a HHSN268201100004C $p WHI NIH HHS $2 United States
- GRA __
- $a U01 CA118444 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN261200800001E $p NCI NIH HHS $2 United States
- GRA __
- $a P30 CA042014 $p NCI NIH HHS $2 United States
- LZP __
- $a Pubmed-20220107
