-
Je něco špatně v tomto záznamu ?
Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death: Results From a Multicenter Randomized Controlled Trial (HOPE ECD-DBD)
Z. Czigany, J. Pratschke, J. Froněk, M. Guba, W. Schöning, DA. Raptis, J. Andrassy, M. Kramer, P. Strnad, RH. Tolba, W. Liu, T. Keller, H. Miller, S. Pavicevic, D. Uluk, M. Kocik, I. Lurje, C. Trautwein, A. Mehrabi, I. Popescu, FWR. Vondran, C....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, randomizované kontrolované studie, práce podpořená grantem
- MeSH
- alografty MeSH
- dárci tkání zásobování a distribuce MeSH
- design vybavení MeSH
- incidence MeSH
- lidé středního věku MeSH
- lidé MeSH
- perfuze přístrojové vybavení MeSH
- pooperační komplikace epidemiologie prevence a kontrola MeSH
- přežívání štěpu MeSH
- senioři MeSH
- terapeutická hypotermie přístrojové vybavení MeSH
- transplantace jater metody MeSH
- uchovávání orgánů přístrojové vybavení MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Geografické názvy
- Evropa MeSH
OBJECTIVE: The aim of this study was to evaluate peak serum alanine aminotransferase (ALT) and postoperative clinical outcomes after hypothermic oxygenated machine perfusion (HOPE) versus static cold storage (SCS) in extended criteria donation (ECD) liver transplantation (LT) from donation after brain death (DBD). BACKGROUND: HOPE might improve outcomes in LT, particularly in high-risk settings such as ECD organs after DBD, but this hypothesis has not yet been tested in a randomized controlled clinical trial (RCT). METHODS: Between September 2017 and September 2020, 46 patients undergoing ECD-DBD LT from four centers were randomly assigned to HOPE (n = 23) or SCS (n = 23). Peak-ALT levels within 7 days following LT constituted the primary endpoint. Secondary endpoints included incidence of postoperative complications [Clavien-Dindo classification (CD), Comprehensive Complication Index (CCI)], length of intensive care- (ICU) and hospital-stay, and incidence of early allograft dysfunction (EAD). RESULTS: Demographics were equally distributed between both groups [donor age: 72 (IQR: 59-78) years, recipient age: 62 (IQR: 55-65) years, labMELD: 15 (IQR: 9-25), 38 male and 8 female recipients]. HOPE resulted in a 47% decrease in serum peak ALT [418 (IQR: 221-828) vs 796 (IQR: 477-1195) IU/L, P = 0.030], a significant reduction in 90-day complications [44% vs 74% CD grade ≥3, P = 0.036; 32 (IQR: 12-56) vs 52 (IQR: 35-98) CCI, P = 0.021], and shorter ICU- and hospital-stays [5 (IQR: 4-8) vs 8 (IQR: 5-18) days, P = 0.045; 20 (IQR: 16-27) vs 36 (IQR: 23-62) days, P = 0.002] compared to SCS. A trend toward reduced EAD was observed for HOPE (17% vs 35%; P = 0.314). CONCLUSION: This multicenter RCT demonstrates that HOPE, in comparison to SCS, significantly reduces early allograft injury and improves post-transplant outcomes in ECD-DBD liver transplantation.
Department for General Visceral and Transplant Surgery Hannover Medical School Hannover Germany
Department of General Surgery and Liver transplantation Fundeni Clinical Institute Bucharest Romania
Department of General Visceral and Transplantation Surgery University of Heidelberg Germany
Department of Hepatology Maastricht University Medical Center Maastricht The Netherlands
Department of HPB Surgery and Liver Transplantation Royal Free Hospital London UK
Department of Internal Medicine 3 University Hospital RWTH Aachen Aachen Germany
Department of Surgery and Transplantation University Hospital RWTH Aachen Aachen Germany
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22003266
- 003
- CZ-PrNML
- 005
- 20220127150517.0
- 007
- ta
- 008
- 220113s2021 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/SLA.0000000000005110 $2 doi
- 035 __
- $a (PubMed)34334635
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Czigany, Zoltan $u Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany
- 245 10
- $a Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death: Results From a Multicenter Randomized Controlled Trial (HOPE ECD-DBD) / $c Z. Czigany, J. Pratschke, J. Froněk, M. Guba, W. Schöning, DA. Raptis, J. Andrassy, M. Kramer, P. Strnad, RH. Tolba, W. Liu, T. Keller, H. Miller, S. Pavicevic, D. Uluk, M. Kocik, I. Lurje, C. Trautwein, A. Mehrabi, I. Popescu, FWR. Vondran, C. Ju, F. Tacke, UP. Neumann, G. Lurje
- 520 9_
- $a OBJECTIVE: The aim of this study was to evaluate peak serum alanine aminotransferase (ALT) and postoperative clinical outcomes after hypothermic oxygenated machine perfusion (HOPE) versus static cold storage (SCS) in extended criteria donation (ECD) liver transplantation (LT) from donation after brain death (DBD). BACKGROUND: HOPE might improve outcomes in LT, particularly in high-risk settings such as ECD organs after DBD, but this hypothesis has not yet been tested in a randomized controlled clinical trial (RCT). METHODS: Between September 2017 and September 2020, 46 patients undergoing ECD-DBD LT from four centers were randomly assigned to HOPE (n = 23) or SCS (n = 23). Peak-ALT levels within 7 days following LT constituted the primary endpoint. Secondary endpoints included incidence of postoperative complications [Clavien-Dindo classification (CD), Comprehensive Complication Index (CCI)], length of intensive care- (ICU) and hospital-stay, and incidence of early allograft dysfunction (EAD). RESULTS: Demographics were equally distributed between both groups [donor age: 72 (IQR: 59-78) years, recipient age: 62 (IQR: 55-65) years, labMELD: 15 (IQR: 9-25), 38 male and 8 female recipients]. HOPE resulted in a 47% decrease in serum peak ALT [418 (IQR: 221-828) vs 796 (IQR: 477-1195) IU/L, P = 0.030], a significant reduction in 90-day complications [44% vs 74% CD grade ≥3, P = 0.036; 32 (IQR: 12-56) vs 52 (IQR: 35-98) CCI, P = 0.021], and shorter ICU- and hospital-stays [5 (IQR: 4-8) vs 8 (IQR: 5-18) days, P = 0.045; 20 (IQR: 16-27) vs 36 (IQR: 23-62) days, P = 0.002] compared to SCS. A trend toward reduced EAD was observed for HOPE (17% vs 35%; P = 0.314). CONCLUSION: This multicenter RCT demonstrates that HOPE, in comparison to SCS, significantly reduces early allograft injury and improves post-transplant outcomes in ECD-DBD liver transplantation.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a alografty $7 D064591
- 650 _2
- $a design vybavení $7 D004867
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a přežívání štěpu $7 D006085
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a terapeutická hypotermie $x přístrojové vybavení $7 D007036
- 650 _2
- $a incidence $7 D015994
- 650 _2
- $a transplantace jater $x metody $7 D016031
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a uchovávání orgánů $x přístrojové vybavení $7 D009926
- 650 _2
- $a perfuze $x přístrojové vybavení $7 D010477
- 650 _2
- $a pooperační komplikace $x epidemiologie $x prevence a kontrola $7 D011183
- 650 _2
- $a dárci tkání $x zásobování a distribuce $7 D014019
- 651 _2
- $a Evropa $x epidemiologie $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Pratschke, Johann $u Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 700 1_
- $a Froněk, Jiří $u Department of Transplantation Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 700 1_
- $a Guba, Markus $u Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
- 700 1_
- $a Schöning, Wenzel $u Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany $u Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 700 1_
- $a Raptis, Dimitri Aristotle $u Department of HPB Surgery and Liver Transplantation, Royal Free Hospital, London, UK $u University College London, London, UK
- 700 1_
- $a Andrassy, Joachim $u Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
- 700 1_
- $a Kramer, Matthijs $u Department of Hepatology, Maastricht University Medical Center (MUMC), Maastricht, The Netherlands
- 700 1_
- $a Strnad, Pavel $u Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany
- 700 1_
- $a Tolba, Rene Hany $u Institute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, Aachen, Germany
- 700 1_
- $a Liu, Wenjia $u Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany
- 700 1_
- $a Keller, Theresa $u Institute for Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany
- 700 1_
- $a Miller, Hannah $u Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany
- 700 1_
- $a Pavicevic, Sandra $u Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 700 1_
- $a Uluk, Deniz $u Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 700 1_
- $a Kocik, Matej $u Department of Transplantation Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 700 1_
- $a Lurje, Isabella $u Department of Hepatology and Gastroenterology, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 700 1_
- $a Trautwein, Christian $u Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany
- 700 1_
- $a Mehrabi, Arianeb $u Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
- 700 1_
- $a Popescu, Irinel $u Department of General Surgery and Liver transplantation, Fundeni Clinical Institute, Bucharest, Romania
- 700 1_
- $a Vondran, Florian Wolfgang Rudolf $u Department for General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany
- 700 1_
- $a Ju, Cynthia $u Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX
- 700 1_
- $a Tacke, Frank $u Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany $u Department of Hepatology and Gastroenterology, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 700 1_
- $a Neumann, Ulf Peter $u Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany
- 700 1_
- $a Lurje, Georg $u Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany $u Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany
- 773 0_
- $w MED00009202 $t Annals of surgery $x 1528-1140 $g Roč. 274, č. 5 (2021), s. 705-712
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34334635 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220113 $b ABA008
- 991 __
- $a 20220127150513 $b ABA008
- 999 __
- $a ok $b bmc $g 1750890 $s 1154415
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 274 $c 5 $d 705-712 $e 20211101 $i 1528-1140 $m Annals of surgery $n Ann Surg $x MED00009202
- LZP __
- $a Pubmed-20220113
