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Prognostic Value of EGFR Exon-20 Insertions in Czech Patients With Advanced Non-small Cell Lung Cancer

J. Skrickova, M. Pesek, P. Opalka, L. Koubkova, M. Zemanova, M. Hrnciarik, J. Blazek, M. Svaton, J. Krejci, H. Coupkova, D. Dolezal, T. Tuzova, L. Holubec, P. Mahadevia, K. Sandstrom, P. Kunovszki, M. Barinova, K. Hurdalkova, O. Fischer, M....

. 2021 ; 41 (11) : 5625-5634. [pub] -

Language English Country Greece

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22003267

BACKGROUND/AIM: Per literature, patients with epidermal growth factor receptor (EGFR) exon-20 insertions respond poorly to tyrosine kinase inhibitors (TKIs). This study analyzed real-world data to examine the prognostic and predictive value of these mutations. PATIENTS AND METHODS: We conducted a retrospective cohort study using Czech TULUNG Registry data, with data on multiple mutation types, collected in 2011-2020. RESULTS: We analyzed 554 (95.85%) patients with EGFR exon-19 deletions or exon-21 L858R substitutions and 24 (4.15%) patients with exon-20 insertions who received first-line high-value therapies. We summarized clinical characteristics and outcomes in all patients and by cohort. The risk of progression was statistically significantly higher (86%) in the exon-20 insertion cohort compared to the cohort with other mutations. Although not statistically significant, the risk of death was 44% higher in patients with exon-20 insertions. CONCLUSION: Advanced NSCLC patients with rare EGFR exon-20 insertions have a high risk of progression.

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$a BACKGROUND/AIM: Per literature, patients with epidermal growth factor receptor (EGFR) exon-20 insertions respond poorly to tyrosine kinase inhibitors (TKIs). This study analyzed real-world data to examine the prognostic and predictive value of these mutations. PATIENTS AND METHODS: We conducted a retrospective cohort study using Czech TULUNG Registry data, with data on multiple mutation types, collected in 2011-2020. RESULTS: We analyzed 554 (95.85%) patients with EGFR exon-19 deletions or exon-21 L858R substitutions and 24 (4.15%) patients with exon-20 insertions who received first-line high-value therapies. We summarized clinical characteristics and outcomes in all patients and by cohort. The risk of progression was statistically significantly higher (86%) in the exon-20 insertion cohort compared to the cohort with other mutations. Although not statistically significant, the risk of death was 44% higher in patients with exon-20 insertions. CONCLUSION: Advanced NSCLC patients with rare EGFR exon-20 insertions have a high risk of progression.
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$a Koubkova, Leona $u Department of Pneumology, Motol University Hospital, Prague, Czech Republic
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$a Blazek, Jiri $u Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic
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$a Coupkova, Helena $u Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
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$a Dolezal, Daniel $u Department of Pneumology, Masaryk Hospital Usti nad Labem, Usti nad Labem, Czech Republic
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$a Tuzova, Tana $u Department of Oncology, Hospital Jihlava, Jihlava, Czech Republic
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$a Fischer, Ondrej $u Department of Pulmonary Diseases and Tuberculosis, University Hospital Olomouc, Olomouc, Czech Republic
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$a Cernovska, Marketa $u Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic
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