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IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

M. Španko, K. Strnadová, AJ. Pavlíček, P. Szabo, O. Kodet, J. Valach, B. Dvořánková, K. Smetana, L. Lacina

. 2021 ; 22 (20) : . [pub] 20211013

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc22003464

Grant support
CZ.02.1.01/0.0/0.0/16_019/0000785 European Structural and Investment Funds; Operational Program Research, Development and Education
PROGRES Q28 Charles University in Prague

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.

References provided by Crossref.org

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