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Muscle strength is associated with COVID-19 hospitalization in adults 50 years of age or older
B. Cheval, S. Sieber, S. Maltagliati, GP. Millet, T. Formánek, A. Chalabaev, S. Cullati, MP. Boisgontier
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
German Ministry of Education and Research
P01_AG08291
US National Institute on Aging
IAG_BSR06-11, OGHA_04-064
US National Institute on Aging
P30_AG12815
US National Institute on Aging
P01_AG005842
US National Institute on Aging
European Commission
R21_AG025169
US National Institute on Aging
U01_AG09740-13S2
US National Institute on Aging
PZ00P1_180040
Swiss National Science Foundation (SNSF)
HHSN271201300071C
NIA NIH HHS - United States
Natural Sciences and Engineering Research Council of Canada (NSERC) : RGPIN-2021-03153
Y1-AG-4553-01
US National Institute on Aging
Max Planck Society for the Advancement of Science
NLK
Directory of Open Access Journals
od 2010
Free Medical Journals
od 2010
PubMed Central
od 2010
Europe PubMed Central
od 2010
ProQuest Central
od 2010-09-01
Open Access Digital Library
od 2010-09-01
Open Access Digital Library
od 2010-01-01
Open Access Digital Library
od 2010-01-01
Health & Medicine (ProQuest)
od 2010-09-01
Wiley Free Content
od 2010
Wiley-Blackwell Open Access Titles
od 2010
ROAD: Directory of Open Access Scholarly Resources
od 2010
PubMed
34363345
DOI
10.1002/jcsm.12738
Knihovny.cz E-zdroje
- MeSH
- COVID-19 * MeSH
- hospitalizace MeSH
- kontrola infekčních nemocí MeSH
- lidé MeSH
- rizikové faktory MeSH
- SARS-CoV-2 MeSH
- senioři MeSH
- svalová síla MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: Weak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization. METHODS: Data from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity. RESULTS: The study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results. CONCLUSIONS: Muscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
Bruyère Research Institute Ottawa Ontario Canada
Department of Public Mental Health National Institute of Mental Health Klecany Czech Republic
Department of Readaptation and Geriatrics University of Geneva Geneva Switzerland
EpiCentre Department of Psychiatry University of Cambridge Cambridge UK
Institute of Sport Sciences University of Lausanne Lausanne Switzerland
Population Health Laboratory University of Fribourg Fribourg Switzerland
SENS Univ Grenoble Alpes Grenoble France
Swiss Center for Affective Sciences University of Geneva Geneva Switzerland
Citace poskytuje Crossref.org
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- $a BACKGROUND: Weak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization. METHODS: Data from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity. RESULTS: The study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results. CONCLUSIONS: Muscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
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