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Determinants of therapeutic lag in multiple sclerosis

I. Roos, E. Leray, F. Frascoli, R. Casey, JWL. Brown, D. Horakova, EK. Havrdova, M. Debouverie, M. Trojano, F. Patti, G. Izquierdo, S. Eichau, G. Edan, A. Prat, M. Girard, P. Duquette, M. Onofrj, A. Lugaresi, P. Grammond, J. Ciron, A. Ruet, S....

. 2021 ; 27 (12) : 1838-1851. [pub] 20210111

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003622

BACKGROUND: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups. OBJECTIVES: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation. METHODS: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants. RESULTS: High baseline disability scores, annualised relapse rate (ARR) ⩾ 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR ⩾ 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS ⩾ 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5). CONCLUSIONS: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag.

Aix Marseille Univ APHM Hôpital de la Timone Pôle de Neurosciences Cliniques Service de Neurologie Marseille France

Amiens University Hospital Department of Neurology place Victor Pauchet Amiens France

Assistance publique des hôpitaux de Paris Department of Neurology Hôpital Henri Mondor Créteil France

Assistance publique des hôpitaux de Paris Hôpital Bicêtre Department of Neurology Le Kremlin Bicêtre France

Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases Istanbul Turkey

Central Clinical School Monash University Melbourne Australia Department of Neurology The Alfred Hospital Melbourne VIC Australia Department of Neurology Box Hill Hospital Monash University Melbourne VIC Australia

Centre hospitalier intercommunal de Poissy Saint Germain en Laye Departement of Neurology Poissy France

Centre hospitalier régional universitaire de Tours Department of Neurology Hôpital Bretonneau CRCSEP Tours France

Centre hospitalier universitaire de Martinique Department of Neurology Hôpital Pierre Zobda Quitman Fort de France France

Centre hospitalier universitaire de Rennes Hôpital Pontchaillou Service de neurologie CIC1414 INSERM Rennes France

Centre hospitalier universitaire de Saint Étienne Department of Neurology Hôpital Nord Saint Étienne France

Centre hospitalier universitaire Limoges Department of Neurology Hôpital Dupuytren Limoges France

Centre hospitalier universitaire Rouen Normandie Hôpital Charles Nicolle Departement of Neurology Rouen France

Centro Hospitalar Universitário de São João and Universidade Fernando Pessoa Porto Portugal

CHU Clermont Ferrand Department of Neurology Clermont Ferrand France Université Clermont Auvergne Inserm Neuro Dol Clermont Ferrand France

CHU de Besançon Department of Neurology Besançon France

CHU de Caen MS Expert Centre Department of Neurology avenue de la Côte de Nacre Normandy University Caen France

CHU de Dijon Department of Neurology EA4184 Dijon France

CHU de Montpellier MS Unit Montpellier France University of Montpellier Montpellier France

CHU de Nantes Service de Neurologie and CIC015 INSERM Nantes France CRTI Inserm U1064 Nantes France

CHU de Nîmes Department of Neurology Nîmes France Institut de Génomique Fonctionnelle UMR5203 INSERM 1191 Université de Montpellier Montpellier France

CHU de Strasbourg Department of Neurology and Clinical Investigation Center CIC INSERM 1434 Strasbourg France

CHU La Milétrie Hôpital Jean Bernard Department of Neurology Poitiers France

CHU Lille CRCSEP Lille Univ Lille U1172 Lille France

CHUM MS Center and Universite de Montreal Montreal QC Canada

CISSS Chaudière Appalache Lévis QC Canada

Cliniques universitaires Saint Luc UCLouvain Bruxelles Belgium

CORe Department of Medicine University of Melbourne Melbourne VIC Australia Department of Clinical Neurosciences University of Cambridge Cambridge UK

CORe Department of Medicine University of Melbourne Melbourne VIC Australia Melbourne MS Centre Department of Neurology Royal Melbourne Hospital Melbourne VIC Australia

CRCSEP Nice UR2CA Université Nice Cote d'Azur Centre hospitalier universitaire de Nice Hopital Pasteur 2 Nice France

CSSS Saint Jérôme Saint Jerome QC Canada

Department of Basic Medical Sciences Neuroscience and Sense Organs University of Bari Bari Italy

Department of Biomedical Metabolic and Neurosciences University of Modena and Reggio Emilia Modena Italy

Department of Clinical Neurosciences University of Cambridge Cambridge UK

Department of Medicine and Surgery University of Parma Parma Italy Department of General Medicine Parma University Hospital Parma Italy

Department of Neurology and Center of Clinical Neuroscience 1st Faculty of Medicine Charles University Prague and General University Hospital Prague Czech Republic

Department of Neurology Centre hospitalier de Pontoise Hôpital René Dubos Pontoise France

Department of Neurology Centre Hospitalier Sud Francilien Corbeil Essonnes France

Department of Neurology Centre hospitalier universitaire Grenoble Alpes La Tronche Grenoble France

Department of Neurology Faculty of Medicine University of Debrecen Debrecen Hungary

Department of Neurology Hôpital Pierre Delafontaine Centre Hospitalier de Saint Denis Saint Denis France

Department of Neurology LR 18 SP03 CIC Neurosciences Razi Hospital La Manouba Tunisia

Department of Neurology LR 18 SP03 CIC Neurosciences Razi Hospital La Manouba Tunisia Faculty of Medicine UTM Tunis Tunisia

Department of Neurology Nancy University Hospital Nancy France Université de Lorraine APEMAC Nancy France

Department of Neurology Zuyderland Medical Center Sittard Geleen The Netherlands

Department of Neuroscience Azienda Ospedaliera Universitaria Modena Italy

Department of Neuroscience Imaging and Clinical Sciences University G d'Annunzio Chieti Italy

Division of Neurology Department of Medicine Amiri Hospital Sharq Kuwait

Dokuz Eylul University Konak Izmir Turkey

Faculty of Science Engineering and Technology School of Science Department of Mathematics Swinburne University of Technology Melbourne VIC Australia

Fondation Adolphe de Rothschild de l'œil et du cerveau Department of Neurology Paris France

GF Ingrassia Department University of Catania Catania Italy Policlinico G Rodolico Catania Italy

Haydarpasa Numune Training and Research Hospital Istanbul Turkey

Hopital Andre Mignot Department of Neurology 177 Rue de Versailles Le Chesnay France

Hôpital Pierre Paul Riquet Department of Neurology CHU de Toulouse CRC SEP Toulouse France

Hospital Universitario Reina Sofia Cordoba Cordoba Spain

Hospital Universitario Virgen Macarena Sevilla Spain

Instituto de Investigación Sanitaria Biodonostia Hospital Universitario Donostia San Sebastian Spain

IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italia Dipartimento di Scienze Biomediche e Neuromotorie Università di Bologna Bologna Italia

IRCCS Mondino Foundation Pavia Italy

KTU Medical Faculty Farabi Hospital Trabzon Turkey

Medical Faculty 19 Mayis University Samsun Turkey

Neuro Rive Sud Quebec QC Canada

Neurological Unit AORN San G Moscati Avellino Italy

Ospedali Riuniti di Salerno Salerno Italy

Rehabilitation and MS Centre Overpelt and Hasselt University Hasselt Belgium

Rennes University EHESP REPERES EA 7449 Rennes France Rennes University CHU Rennes Inserm CIC 1414 [ ] Rennes France

School of Medicine and Public Health University Newcastle Newcastle NSW Australia Department of Neurology John Hunter Hospital Hunter New England Health Newcastle NSW Australia

Service de neurologie sclérose en plaques pathologies de la myéline et neuro inflammation Hôpital Neurologique Pierre Wertheimer Hospices Civils de Lyon Lyon Bron France Centre des Neurosciences de Lyon Observatoire Français de la Sclérose en Plaques INSERM 1028 et CNRS UMR5292 Lyon France Université Claude Bernard Lyon 1 Faculté de médecine Lyon Est Lyon France

Sorbonne Université Institut du Cerveau ICM Assistance Publique Hôpitaux de Paris APHP Département de neurologie Hôpital de la Pitié Salpêtrière Paris France

Sorbonne Universités UPMC Paris 06 Brain and Spine Institute ICM Hôpital de la Pitié Salpêtrière Inserm UMR S 1127 CNRS UMR 7225 Pars France Department of Neurology AP HP Saint Antoine Hospital Paris France

Université de Lyon Université Claude Bernard Lyon 1 Lyon France Hospices Civils de Lyon Service de Neurologie sclérose en plaques pathologies de la myéline et neuro inflammation Bron France Observatoire Français de la Sclérose en Plaques Centre de Recherche en Neurosciences de Lyon INSERM 1028 et CNRS UMR 5292 Lyon France EUGENE DEVIC EDMUS Foundation Against Multiple Sclerosis State Approved Foundation Bron France

University Bordeaux Bordeaux France INSERM U1215 Neurocentre Magendie Bordeaux France Department of Neurology CHU de Bordeaux CIC Bordeaux CIC1401 Bordeaux France

University of Queensland Brisbane QLD Australia Royal Brisbane and Women's Hospital Herston QLD Australia

UOC Neurologia Azienda Sanitaria Unica Regionale Marche AV3 Macerata Italy

Citace poskytuje Crossref.org

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$a Determinants of therapeutic lag in multiple sclerosis / $c I. Roos, E. Leray, F. Frascoli, R. Casey, JWL. Brown, D. Horakova, EK. Havrdova, M. Debouverie, M. Trojano, F. Patti, G. Izquierdo, S. Eichau, G. Edan, A. Prat, M. Girard, P. Duquette, M. Onofrj, A. Lugaresi, P. Grammond, J. Ciron, A. Ruet, S. Ozakbas, J. De Seze, C. Louapre, H. Zephir, MJ. Sá, P. Sola, D. Ferraro, P. Labauge, G. Defer, R. Bergamaschi, C. Lebrun-Frenay, C. Boz, E. Cartechini, T. Moreau, D. Laplaud, J. Lechner-Scott, F. Grand'Maison, O. Gerlach, M. Terzi, F. Granella, R. Alroughani, G. Iuliano, V. Van Pesch, B. Van Wijmeersch, D. Spitaleri, A. Soysal, E. Berger, J. Prevost, E. Aguera-Morales, P. McCombe, T. Castillo Triviño, P. Clavelou, J. Pelletier, R. Turkoglu, B. Stankoff, O. Gout, E. Thouvenot, O. Heinzlef, Y. Sidhom, R. Gouider, T. Csepany, B. Bourre, A. Al Khedr, O. Casez, P. Cabre, A. Montcuquet, A. Wahab, JP. Camdessanche, A. Maurousset, I. Patry, K. Hankiewicz, C. Pottier, N. Maubeuge, C. Labeyrie, C. Nifle, A. Coles, CB. Malpas, S. Vukusic, H. Butzkueven, T. Kalincik
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$a BACKGROUND: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups. OBJECTIVES: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation. METHODS: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants. RESULTS: High baseline disability scores, annualised relapse rate (ARR) ⩾ 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR ⩾ 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS ⩾ 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5). CONCLUSIONS: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag.
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$a Trojano, Maria $u Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy
700    1_
$a Patti, Francesco $u GF Ingrassia Department, University of Catania, Catania, Italy/Policlinico G Rodolico, Catania, Italy
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$a Izquierdo, Guillermo $u Hospital Universitario Virgen Macarena, Sevilla, Spain
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$a Eichau, Sara $u Hospital Universitario Virgen Macarena, Sevilla, Spain
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$a Edan, Gilles $u Centre hospitalier universitaire de Rennes, Hôpital Pontchaillou, Service de neurologie, CIC1414 INSERM, Rennes, France
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$a Prat, Alexandre $u CHUM MS Center and Universite de Montreal, Montreal, QC, Canada
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$a Girard, Marc $u CHUM MS Center and Universite de Montreal, Montreal, QC, Canada
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$a Duquette, Pierre $u CHUM MS Center and Universite de Montreal, Montreal, QC, Canada
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$a Onofrj, Marco $u Department of Neuroscience, Imaging, and Clinical Sciences, University G. d'Annunzio, Chieti, Italy
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$a Lugaresi, Alessandra $u IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italia/Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italia
700    1_
$a Grammond, Pierre $u CISSS Chaudière-Appalache, Lévis, QC, Canada
700    1_
$a Ciron, Jonathan $u Hôpital Pierre-Paul Riquet, Department of Neurology, CHU de Toulouse, CRC-SEP, Toulouse, France
700    1_
$a Ruet, Aurélie $u University Bordeaux, Bordeaux, France/INSERM U1215, Neurocentre Magendie, Bordeaux, France/Department of Neurology, CHU de Bordeaux, CIC Bordeaux CIC1401, Bordeaux, France
700    1_
$a Ozakbas, Serkan $u Dokuz Eylul University, Konak/Izmir, Turkey
700    1_
$a De Seze, Jérôme $u CHU de Strasbourg, Department of Neurology and Clinical Investigation Center, CIC (centre d'investigation clinique) INSERM 1434, Strasbourg, France
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$a Louapre, Céline $u Sorbonne Université, Institut du Cerveau, ICM, Assistance Publique Hôpitaux de Paris APHP, Département de neurologie, Hôpital de la Pitié Salpêtrière, Paris, France
700    1_
$a Zephir, Hélène $u CHU Lille, CRCSEP Lille, Univ Lille, U1172, Lille, France
700    1_
$a Sá, Maria José $u Centro Hospitalar Universitário de São João and Universidade Fernando Pessoa, Porto, Portugal
700    1_
$a Sola, Patrizia $u Department of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italy
700    1_
$a Ferraro, Diana $u Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy
700    1_
$a Labauge, Pierre $u CHU de Montpellier, MS Unit, Montpellier, France/University of Montpellier (MUSE), Montpellier, France
700    1_
$a Defer, Gilles $u CHU de Caen, MS Expert Centre, Department of Neurology, avenue de la Côte-de-Nacre, Normandy University, Caen, France
700    1_
$a Bergamaschi, Roberto $u IRCCS Mondino Foundation, Pavia, Italy
700    1_
$a Lebrun-Frenay, Christine $u CRCSEP Nice, UR2CA, Université Nice Cote d'Azur, Centre hospitalier universitaire de Nice, Hopital Pasteur 2, Nice, France
700    1_
$a Boz, Cavit $u KTU Medical Faculty Farabi Hospital, Trabzon, Turkey
700    1_
$a Cartechini, Elisabetta $u UOC Neurologia, Azienda Sanitaria Unica Regionale Marche - AV3, Macerata, Italy
700    1_
$a Moreau, Thibault $u CHU de Dijon, Department of Neurology, EA4184, Dijon, France
700    1_
$a Laplaud, David $u CHU de Nantes, Service de Neurologie & CIC015 INSERM, Nantes, France/CRTI-Inserm U1064, Nantes, France
700    1_
$a Lechner-Scott, Jeannette $u School of Medicine and Public Health, University Newcastle, Newcastle, NSW, Australia/Department of Neurology, John Hunter Hospital, Hunter New England Health, Newcastle, NSW, Australia
700    1_
$a Grand'Maison, Francois $u Neuro Rive-Sud, Quebec, QC, Canada
700    1_
$a Gerlach, Oliver $u Department of Neurology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands
700    1_
$a Terzi, Murat $u Medical Faculty, 19 Mayis University, Samsun, Turkey
700    1_
$a Granella, Franco $u Department of Medicine and Surgery, University of Parma, Parma, Italy/Department of General Medicine, Parma University Hospital, Parma, Italy
700    1_
$a Alroughani, Raed $u Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait
700    1_
$a Iuliano, Gerardo $u Ospedali Riuniti di Salerno, Salerno, Italy
700    1_
$a Van Pesch, Vincent $u Cliniques universitaires Saint-Luc, UCLouvain, Bruxelles, Belgium
700    1_
$a Van Wijmeersch, Bart $u Rehabilitation and MS-Centre Overpelt and Hasselt University, Hasselt, Belgium
700    1_
$a Spitaleri, Daniele LA $u Neurological Unit AORN San G. Moscati, Avellino, Italy
700    1_
$a Soysal, Aysun $u Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey
700    1_
$a Berger, Eric $u CHU de Besançon, Department of Neurology, Besançon, France
700    1_
$a Prevost, Julie $u CSSS Saint-Jérôme, Saint-Jerome, QC, Canada
700    1_
$a Aguera-Morales, Eduardo $u Hospital Universitario Reina Sofia Cordoba (IMIBIC), Cordoba, Spain
700    1_
$a McCombe, Pamela $u University of Queensland, Brisbane, QLD, Australia/Royal Brisbane and Women's Hospital, Herston, QLD, Australia
700    1_
$a Castillo Triviño, Tamara $u Instituto de Investigación Sanitaria Biodonostia, Hospital Universitario Donostia, San Sebastian, Spain
700    1_
$a Clavelou, Pierre $u CHU Clermont-Ferrand, Department of Neurology, Clermont-Ferrand, France/Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France
700    1_
$a Pelletier, Jean $u Aix Marseille Univ, APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France
700    1_
$a Turkoglu, Recai $u Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey
700    1_
$a Stankoff, Bruno $u Sorbonne Universités, UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de la Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, Pars, France/Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France
700    1_
$a Gout, Olivier $u Fondation Adolphe de Rothschild de l'œil et du cerveau, Department of Neurology, Paris, France
700    1_
$a Thouvenot, Eric $u CHU de Nîmes, Department of Neurology, Nîmes, France/Institut de Génomique Fonctionnelle, UMR5203, INSERM 1191, Université de Montpellier, Montpellier, France
700    1_
$a Heinzlef, Olivier $u Centre hospitalier intercommunal de Poissy Saint-Germain-en-Laye, Departement of Neurology, Poissy, France
700    1_
$a Sidhom, Youssef $u Department of Neurology - LR 18 SP03 - CIC Neurosciences, Razi Hospital, La Manouba, Tunisia
700    1_
$a Gouider, Riadh $u Department of Neurology - LR 18 SP03 - CIC Neurosciences, Razi Hospital, La Manouba, Tunisia/Faculty of Medicine, UTM, Tunis, Tunisia
700    1_
$a Csepany, Tunde $u Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
700    1_
$a Bourre, Bertrand $u Centre hospitalier universitaire Rouen Normandie, Hôpital Charles-Nicolle, Departement of Neurology, Rouen, France
700    1_
$a Al Khedr, Abdullatif $u Amiens University Hospital, Department of Neurology, place Victor Pauchet, Amiens, France
700    1_
$a Casez, Olivier $u Department of Neurology, Centre hospitalier universitaire Grenoble-Alpes, La Tronche/Grenoble, France
700    1_
$a Cabre, Philippe $u Centre hospitalier universitaire de Martinique, Department of Neurology, Hôpital Pierre Zobda-Quitman, Fort-de-France, France
700    1_
$a Montcuquet, Alexis $u Centre hospitalier universitaire Limoges, Department of Neurology, Hôpital Dupuytren, Limoges, France
700    1_
$a Wahab, Abir $u Assistance publique des hôpitaux de Paris, Department of Neurology, Hôpital Henri Mondor, Créteil, France
700    1_
$a Camdessanche, Jean-Philippe $u Centre hospitalier universitaire de Saint-Étienne, Department of Neurology, Hôpital Nord, Saint-Étienne, France
700    1_
$a Maurousset, Aude $u Centre hospitalier régional universitaire de Tours, Department of Neurology, Hôpital Bretonneau, CRCSEP, Tours, France
700    1_
$a Patry, Ivania $u Department of Neurology, Centre Hospitalier Sud Francilien, Corbeil Essonnes, France
700    1_
$a Hankiewicz, Karolina $u Department of Neurology, Hôpital Pierre Delafontaine, Centre Hospitalier de Saint-Denis, Saint-Denis, France
700    1_
$a Pottier, Corinne $u Department of Neurology, Centre hospitalier de Pontoise, Hôpital René Dubos, Pontoise, France
700    1_
$a Maubeuge, Nicolas $u CHU La Milétrie, Hôpital Jean Bernard, Department of Neurology, Poitiers, France
700    1_
$a Labeyrie, Céline $u Assistance publique des hôpitaux de Paris, Hôpital Bicêtre, Department of Neurology, Le Kremlin Bicêtre, France
700    1_
$a Nifle, Chantal $u Hopital Andre Mignot, Department of Neurology, 177 Rue de Versailles, Le Chesnay, France
700    1_
$a Coles, Alasdair $u Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
700    1_
$a Malpas, Charles B $u CORe, Department of Medicine, University of Melbourne, Melbourne, VIC, Australia/Melbourne MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia
700    1_
$a Vukusic, Sandra $u Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron, France/Centre des Neurosciences de Lyon, Observatoire Français de la Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, Lyon, France/Université Claude Bernard Lyon 1, Faculté de médecine Lyon Est, Lyon, France
700    1_
$a Butzkueven, Helmut $u Central Clinical School, Monash University, Melbourne, Australia/Department of Neurology, The Alfred Hospital, Melbourne, VIC, Australia/Department of Neurology, Box Hill Hospital, Monash University, Melbourne, VIC, Australia
700    1_
$a Kalincik, Tomas $u CORe, Department of Medicine, University of Melbourne, Melbourne, VIC, Australia/Melbourne MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia
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