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Controlled Anchoring of (Phenylureido)sulfonamide-Based Receptor Moieties: An Impact of Binding Site Multiplication on Complexation Properties
K. Salvadori, A. Krupková, LČ. Šťastná, M. Müllerová, V. Eigner, T. Strašák, P. Cuřínová
Language English Country Switzerland
Document type Journal Article
Grant support
20-07833S
Grantová Agentura České Republiky
A2_FCHI_2021_002
Ministerstvo Školství, Mládeže a Tělovýchovy
NLK
Directory of Open Access Journals
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PubMed Central
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from 1997-01-01
- MeSH
- Magnetic Resonance Spectroscopy * MeSH
- Models, Molecular MeSH
- Sulfonamides * MeSH
- Publication type
- Journal Article MeSH
The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and 1H-NMR in classical or competitive titration mode, the attachment to a carrier allocates the active moieties to mutual positions predetermining the function of the whole receptor molecule. Bivalent receptors form self-aggregates. Dendritic receptors with low dihydrogen phosphate loadings offer a cooperative complexation mode associated with a positive dendritic effect. In higher dihydrogen phosphate concentrations, the dendritic branches act independently and the binding mode changes to 1:1 anion: complexation site. Despite the anchoring, the dendritic receptors retain the superior efficiency and selectivity of a monomer, paving the way to recyclable receptors, desirable for economic and ecological reasons.
References provided by Crossref.org
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