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Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies
D. Ferreira, Z. Nedelska, J. Graff-Radford, SA. Przybelski, TG. Lesnick, CG. Schwarz, H. Botha, ML. Senjem, JA. Fields, DS. Knopman, R. Savica, TJ. Ferman, NR. Graff-Radford, VJ. Lowe, CR. Jack, RC. Petersen, AW. Lemstra, M. van de Beek, F....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
R01 AG041851
NIA NIH HHS - United States
C06 RR018898
NCRR NIH HHS - United States
P50 AG016574
NIA NIH HHS - United States
R01 AG040042
NIA NIH HHS - United States
Department of Health - United Kingdom
R01 AG011378
NIA NIH HHS - United States
R01 NS080820
NINDS NIH HHS - United States
R37 AG011378
NIA NIH HHS - United States
U01 NS100620
NINDS NIH HHS - United States
U01 AG006786
NIA NIH HHS - United States
- MeSH
- bílá hmota diagnostické zobrazování patologie MeSH
- cerebrovaskulární poruchy komplikace MeSH
- degenerace nervu etiologie MeSH
- demence s Lewyho tělísky diagnostické zobrazování etiologie patologie psychologie MeSH
- halucinace MeSH
- kognice MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozková kůra krevní zásobení diagnostické zobrazování patologie MeSH
- mozkový infarkt diagnostické zobrazování patologie MeSH
- porucha chování v REM spánku etiologie MeSH
- šedá hmota diagnostické zobrazování patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
We investigated whether cerebrovascular disease contributes to neurodegeneration and clinical phenotype in dementia with Lewy bodies (DLB). Regional cortical thickness and subcortical gray matter volumes were estimated from structural magnetic resonance imaging (MRI) in 165 DLB patients. Cortical and subcortical infarcts were recorded and white matter hyperintensities (WMHs) were assessed. Subcortical only infarcts were more frequent (13.3%) than cortical only infarcts (3.1%) or both subcortical and cortical infarcts (2.4%). Infarcts, irrespective of type, were associated with WMHs. A higher WMH volume was associated with thinner orbitofrontal, retrosplenial, and posterior cingulate cortices, smaller thalamus and pallidum, and larger caudate volume. A higher WMH volume was associated with the presence of visual hallucinations and lower global cognitive performance, and tended to be associated with the absence of probable rapid eye movement sleep behavior disorder. Presence of infarcts was associated with the absence of parkinsonism. We conclude that cerebrovascular disease is associated with gray matter neurodegeneration in patients with probable DLB, which may have implications for the multifactorial treatment of probable DLB.
Centre for Age Related Medicine Stavanger University Hospital Stavanger Norway
Department of Electrical Engineering and Computer Science University of Stavanger Stavanger Norway
Department of Health Sciences Mayo Clinic Rochester MN USA
Department of Information Technology Mayo Clinic Rochester MN USA
Department of Neurology and Alzheimer Center VU University Medical Center Amsterdam Netherlands
Department of Neurology Mayo Clinic Jacksonville FL USA
Department of Neurology Mayo Clinic Rochester MN USA
Department of Psychiatry and Psychology Mayo Clinic Jacksonville FL
Department of Psychiatry and Psychology Mayo Clinic Rochester MN USA
Department of Radiology and Nuclear Medicine VU University Medical Center Amsterdam Netherlands
Department of Radiology Mayo Clinic Rochester MN USA
Institute of Psychiatry Psychology and Neuroscience King's College London London UK
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
Queen Square Institute of Neurology University College London London UK
University of Strasbourg and French National Centre for Scientific Research ICONE Strasbourg France
Citace poskytuje Crossref.org
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