A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)

Annotation

LEWY BODY PARKINSON DISEASE see PARKINSON DISEASE is also available

DUI

D020961 MeSH Browser

CUI

M0015964

Previous indexing

Alzheimer Disease (1979-1999); Parkinson Disease (1977-1999); Parkinson Disease, Secondary (1984-1999)

History note

2000; use PARKINSON DISEASE 1992-1999; for DIFFUSE LEWY BODY DISEASE & LEWY BODY DISEASE, DIFFUSE use PARKINSON DISEASE 1992-1999

Public note

2000; see PARKINSON DISEASE 1992-1999; for DIFFUSE LEWY BODY DISEASE & LEWY BODY DISEASE, DIFFUSE see PARKINSON DISEASE 1992-1999