• Je něco špatně v tomto záznamu ?

Nuclear tRNA export in trypanosomes: a journey full of twists and turns guided by tRNA modifications

Z. Paris

. 2021 ; 148 (10) : 1219-1222. [pub] 20210317

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003852

Transfer RNAs play a key role in protein synthesis. Following transcription, tRNAs are extensively processed prior to their departure from the nucleus to become fully functional during translation. This includes removal of 5′ leaders and 3′ trailers by a specific endo- and/or exonuclease, 3′ CCA tail addition, posttranscriptional modifications and in some cases intron removal. In this minireview, the critical factors of nuclear tRNA trafficking are described based on studies in classical models such as yeast and human cell lines. In addition, recent findings and identification of novel regulatory loops of nuclear tRNA trafficking in trypanosomes are discussed with emphasis on tRNA modifications. The comparison between the representatives of opisthokonts and excavates serves here to understand the evolutionary conservation and diversity of nuclear tRNA export mechanisms.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22003852
003      
CZ-PrNML
005      
20220127145807.0
007      
ta
008      
220113s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1017/S0031182021000482 $2 doi
035    __
$a (PubMed)33729118
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Paris, Zdeněk $u Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice (Budweiss), Czech Republic $u Faculty of Science, University of South Bohemia, České Budějovice (Budweiss), Czech Republic
245    10
$a Nuclear tRNA export in trypanosomes: a journey full of twists and turns guided by tRNA modifications / $c Z. Paris
520    9_
$a Transfer RNAs play a key role in protein synthesis. Following transcription, tRNAs are extensively processed prior to their departure from the nucleus to become fully functional during translation. This includes removal of 5′ leaders and 3′ trailers by a specific endo- and/or exonuclease, 3′ CCA tail addition, posttranscriptional modifications and in some cases intron removal. In this minireview, the critical factors of nuclear tRNA trafficking are described based on studies in classical models such as yeast and human cell lines. In addition, recent findings and identification of novel regulatory loops of nuclear tRNA trafficking in trypanosomes are discussed with emphasis on tRNA modifications. The comparison between the representatives of opisthokonts and excavates serves here to understand the evolutionary conservation and diversity of nuclear tRNA export mechanisms.
650    _2
$a buněčné linie $7 D002460
650    _2
$a lidé $7 D006801
650    _2
$a RNA jaderná $x genetika $x metabolismus $7 D015138
650    _2
$a RNA transferová $x genetika $x metabolismus $7 D012343
650    _2
$a Saccharomyces cerevisiae $x genetika $x metabolismus $7 D012441
650    _2
$a Trypanosoma $x genetika $x metabolismus $7 D014345
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
773    0_
$w MED00010377 $t Parasitology $x 1469-8161 $g Roč. 148, č. 10 (2021), s. 1219-1222
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33729118 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145803 $b ABA008
999    __
$a ok $b bmc $g 1751347 $s 1155001
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 148 $c 10 $d 1219-1222 $e 20210317 $i 1469-8161 $m Parasitology $n Parasitology $x MED00010377
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace