• Je něco špatně v tomto záznamu ?

FasL Is Required for Osseous Healing in Extraction Sockets in Mice

KA. Apaza Alccayhuaman, P. Heimel, JS. Lee, S. Tangl, FJ. Strauss, A. Stähli, E. Matalová, R. Gruber

. 2021 ; 12 (-) : 678873. [pub] 20210531

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004309

Fas ligand (FasL) is a member of the tumor necrosis factor (TNF) superfamily involved in the activation of apoptosis. Assuming that apoptosis is initiated after tooth extraction it is reasonable to suggest that FasL may play a pivotal role in the healing of extraction sockets. Herein, we tested the hypothesis of whether the lack of FasL impairs the healing of extraction sockets. To this end, we extracted upper right incisors of FasL knockout (KO) mice and their wildtype (WT) littermates. After a healing period of two weeks, bone volume over total volume (BV/TV) via µCT and descriptive histological analyses were performed. µCT revealed that BV/TV in the coronal region of the socket amounted to 39.4% in WT and 21.8% in KO, with a significant difference between the groups (p=0.002). Likewise, in the middle region of the socket, BV/TV amounted to 50.3% in WT and 40.8% in KO (p<0.001). In the apical part, however, no difference was noticed. Consistently, WT mice displayed a significantly higher median trabecular thickness and a lower trabecular separation when compared to the KO group at the coronal and central region of the socket. There was the overall tendency that in both, female and male mice, FasL affects bone regeneration. Taken together, these findings suggest that FasL deficiency may reduce bone regeneration during the healing process of extraction sockets.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004309
003      
CZ-PrNML
005      
20220127145341.0
007      
ta
008      
220113s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fimmu.2021.678873 $2 doi
035    __
$a (PubMed)34135904
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Apaza Alccayhuaman, Karol Alí $u Department of Oral Biology, Medical University of Vienna, Vienna, Austria $u Karl Donath Laboratory for Hard Tissue and Biomaterial Research, School of Dentistry, Medical University of Vienna, Vienna, Austria
245    10
$a FasL Is Required for Osseous Healing in Extraction Sockets in Mice / $c KA. Apaza Alccayhuaman, P. Heimel, JS. Lee, S. Tangl, FJ. Strauss, A. Stähli, E. Matalová, R. Gruber
520    9_
$a Fas ligand (FasL) is a member of the tumor necrosis factor (TNF) superfamily involved in the activation of apoptosis. Assuming that apoptosis is initiated after tooth extraction it is reasonable to suggest that FasL may play a pivotal role in the healing of extraction sockets. Herein, we tested the hypothesis of whether the lack of FasL impairs the healing of extraction sockets. To this end, we extracted upper right incisors of FasL knockout (KO) mice and their wildtype (WT) littermates. After a healing period of two weeks, bone volume over total volume (BV/TV) via µCT and descriptive histological analyses were performed. µCT revealed that BV/TV in the coronal region of the socket amounted to 39.4% in WT and 21.8% in KO, with a significant difference between the groups (p=0.002). Likewise, in the middle region of the socket, BV/TV amounted to 50.3% in WT and 40.8% in KO (p<0.001). In the apical part, however, no difference was noticed. Consistently, WT mice displayed a significantly higher median trabecular thickness and a lower trabecular separation when compared to the KO group at the coronal and central region of the socket. There was the overall tendency that in both, female and male mice, FasL affects bone regeneration. Taken together, these findings suggest that FasL deficiency may reduce bone regeneration during the healing process of extraction sockets.
650    _2
$a zvířata $7 D000818
650    _2
$a biologické markery $7 D015415
650    _2
$a kostní denzita $7 D015519
650    12
$a regenerace kostí $x genetika $7 D001861
650    _2
$a ligand Fas $x genetika $x metabolismus $7 D053222
650    _2
$a imunohistochemie $7 D007150
650    _2
$a myši $7 D051379
650    _2
$a modely u zvířat $7 D023421
650    _2
$a velikost orgánu $7 D009929
650    12
$a extrakce zubů $7 D014081
650    _2
$a hojení ran $x fyziologie $7 D014945
650    _2
$a rentgenová mikrotomografie $7 D055114
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Heimel, Patrick $u Karl Donath Laboratory for Hard Tissue and Biomaterial Research, School of Dentistry, Medical University of Vienna, Vienna, Austria $u Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria $u Austrian Cluster for Tissue Regeneration, Medical University of Vienna, Vienna, Austria
700    1_
$a Lee, Jung-Seok $u Department of Oral Biology, Medical University of Vienna, Vienna, Austria $u Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea
700    1_
$a Tangl, Stefan $u Karl Donath Laboratory for Hard Tissue and Biomaterial Research, School of Dentistry, Medical University of Vienna, Vienna, Austria $u Austrian Cluster for Tissue Regeneration, Medical University of Vienna, Vienna, Austria
700    1_
$a Strauss, Franz J $u Department of Oral Biology, Medical University of Vienna, Vienna, Austria $u Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland $u Department of Conservative Dentistry, School of Dentistry, University of Chile, Santiago, Chile
700    1_
$a Stähli, Alexandra $u Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
700    1_
$a Matalová, Eva $u Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
700    1_
$a Gruber, Reinhard $u Department of Oral Biology, Medical University of Vienna, Vienna, Austria $u Austrian Cluster for Tissue Regeneration, Medical University of Vienna, Vienna, Austria $u Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
773    0_
$w MED00181405 $t Frontiers in immunology $x 1664-3224 $g Roč. 12, č. - (2021), s. 678873
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34135904 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145338 $b ABA008
999    __
$a ok $b bmc $g 1751700 $s 1155458
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 12 $c - $d 678873 $e 20210531 $i 1664-3224 $m Frontiers in immunology $n Front Immunol $x MED00181405
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

    Možnosti archivace