-
Je něco špatně v tomto záznamu ?
Manganese and copper levels in patients with primary biliary cirrhosis and primary sclerosing cholangitis
M. Dastych, L. Husová, K. Aiglová, T. Fejfar, M. Dastych
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, pozorovací studie
- MeSH
- biliární cirhóza krev terapie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mangan krev MeSH
- měď krev MeSH
- mladý dospělý MeSH
- senioři MeSH
- sklerozující cholangitida krev terapie MeSH
- studie případů a kontrol MeSH
- transplantace jater MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
The liver and the biliary tree form the main excretory route of manganese (Mn) and copper (Cu). Cholestasis, can lead to the accumulation of these trace elements in the organism, resulting in toxicity to the basal ganglia of the central nervous system. The aim of our study was to reveal the influence of long-term cholestasis on the Mn and Cu levels in the blood of patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). We recruited patients with PBC (n = 20) and PSC (n = 32). A control group (n = 40) was also set up. We also examined serum bile acid concentrations and liver enzyme activities. We did not observe any significant differences in any of these parameters between the PBC and PSC groups. The Mn and Cu levels in the PBC and PSC patients differed significantly from the that in the control group (p < 0.0001 and p < .021, respectively). Patients in whom the laboratory cholestasis markers normalized during ursodeoxycholic acid treatment (18/52;35%) presented with significantly lower levels of Mn and Cu (p = .015 and p = .012, respectively). Ten PSC patients showed normal levels of Mn and Cu six months after liver transplantation. Fine tremors, rigidity, dysarthria, and hypomimia were reported in nine (23%), eight (20%), four (10%), and eight (20%) patients, respectively. In addition to monitoring the cholestasis levels, liver function, and Mn and Cu levels during the long-term treatment of PBC and PSC patients, it is important to also regularly monitor the occurrence and development of extrapyramidal symptoms of Parkinson's-like syndromes.
Center for Cardiovascular Surgery and Transplantation Brno Czech Republic
Department of Clinical Biochemistry University Hospital Brno Brno Czech Republic
Department of Gastroenterology and Internal Medicine University Hospital Brno Brno Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22004504
- 003
- CZ-PrNML
- 005
- 20220127145203.0
- 007
- ta
- 008
- 220113s2021 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/00365513.2020.1864835 $2 doi
- 035 __
- $a (PubMed)33428478
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Dastych, Milan $u Department of Clinical Biochemistry, University Hospital Brno, Brno, Czech Republic
- 245 10
- $a Manganese and copper levels in patients with primary biliary cirrhosis and primary sclerosing cholangitis / $c M. Dastych, L. Husová, K. Aiglová, T. Fejfar, M. Dastych
- 520 9_
- $a The liver and the biliary tree form the main excretory route of manganese (Mn) and copper (Cu). Cholestasis, can lead to the accumulation of these trace elements in the organism, resulting in toxicity to the basal ganglia of the central nervous system. The aim of our study was to reveal the influence of long-term cholestasis on the Mn and Cu levels in the blood of patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). We recruited patients with PBC (n = 20) and PSC (n = 32). A control group (n = 40) was also set up. We also examined serum bile acid concentrations and liver enzyme activities. We did not observe any significant differences in any of these parameters between the PBC and PSC groups. The Mn and Cu levels in the PBC and PSC patients differed significantly from the that in the control group (p < 0.0001 and p < .021, respectively). Patients in whom the laboratory cholestasis markers normalized during ursodeoxycholic acid treatment (18/52;35%) presented with significantly lower levels of Mn and Cu (p = .015 and p = .012, respectively). Ten PSC patients showed normal levels of Mn and Cu six months after liver transplantation. Fine tremors, rigidity, dysarthria, and hypomimia were reported in nine (23%), eight (20%), four (10%), and eight (20%) patients, respectively. In addition to monitoring the cholestasis levels, liver function, and Mn and Cu levels during the long-term treatment of PBC and PSC patients, it is important to also regularly monitor the occurrence and development of extrapyramidal symptoms of Parkinson's-like syndromes.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a sklerozující cholangitida $x krev $x terapie $7 D015209
- 650 _2
- $a měď $x krev $7 D003300
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a biliární cirhóza $x krev $x terapie $7 D008105
- 650 _2
- $a transplantace jater $7 D016031
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a mangan $x krev $7 D008345
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a pozorovací studie $7 D064888
- 700 1_
- $a Husová, Libuše $u Center for Cardiovascular Surgery and Transplantation, Brno, Czech Republic
- 700 1_
- $a Aiglová, Květoslava $u Department of Internal Medicine II - Gastroenterology and Geriatrics, University Hospital Olomouc, Olomouc, Czech Republic
- 700 1_
- $a Fejfar, Tomáš $u 2nd Department of Internal Medicine Gastroenterology, University Hospital Hradec Králové, Hradec Králové, Czech Republic
- 700 1_
- $a Dastych, Milan $u Department of Gastroenterology and Internal Medicine, University Hospital Brno, Brno, Czech Republic $u Faculty of Medicine Masaryk University, Brno, Czech Republic
- 773 0_
- $w MED00010597 $t Scandinavian journal of clinical and laboratory investigation $x 1502-7686 $g Roč. 81, č. 2 (2021), s. 116-120
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33428478 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220113 $b ABA008
- 991 __
- $a 20220127145200 $b ABA008
- 999 __
- $a ok $b bmc $g 1751845 $s 1155653
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 81 $c 2 $d 116-120 $e 20210111 $i 1502-7686 $m Scandinavian journal of clinical & laboratory investigation $n Scand J Clin Lab Invest $x MED00010597
- LZP __
- $a Pubmed-20220113
