Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study

J. Stranik, M. Kacerovsky, O. Soucek, M. Kolackova, I. Musilova, L. Pliskova, R. Bolehovska, P. Bostik, J. Matulova, B. Jacobsson, C. Andrys

. 2021 ; 11 (1) : 6107. [pub] 20210317

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004528

To determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic inflammation). In this study, we included 170 and 79 women with PPROM and PTL, respectively. Paired cervical and amniotic fluid samples were obtained using a Dacron polyester swab and transabdominal amniocentesis, respectively. The FcgammaBP concentrations in the samples were assessed using an enzyme-linked immunosorbent assay. The presence of intra-amniotic infection was associated with elevated FcgammaBP concentrations in pregnancies with PPROM and PTL [PPROM-presence: 86 ng/mL vs. absence: 13 ng/mL, p < 0.0001, area under receiver operating characteristic curve (AUC) = 0.94; PTL-presence: 140 ng/mL vs. absence: 22 ng/mL, p < 0.0001, AUC = 0.86]. In cervical fluid, the concentrations of FcgammaBP were elevated in the presence of intra-amniotic infection in pregnancies with PPROM only (presence: 345 ng/mL vs. absence: 60 ng/mL, p < 0.0001, AUC = 0.93). FcgammaBP in amniotic fluid might be a marker of intra-amniotic infection in women with both PPROM and PTL However, in cervical fluid, it is only observed in women with PPROM.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004528
003      
CZ-PrNML
005      
20220127145156.0
007      
ta
008      
220113s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-021-85473-2 $2 doi
035    __
$a (PubMed)33731725
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Stranik, Jaroslav $u The Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic
245    10
$a IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study / $c J. Stranik, M. Kacerovsky, O. Soucek, M. Kolackova, I. Musilova, L. Pliskova, R. Bolehovska, P. Bostik, J. Matulova, B. Jacobsson, C. Andrys
520    9_
$a To determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic inflammation). In this study, we included 170 and 79 women with PPROM and PTL, respectively. Paired cervical and amniotic fluid samples were obtained using a Dacron polyester swab and transabdominal amniocentesis, respectively. The FcgammaBP concentrations in the samples were assessed using an enzyme-linked immunosorbent assay. The presence of intra-amniotic infection was associated with elevated FcgammaBP concentrations in pregnancies with PPROM and PTL [PPROM-presence: 86 ng/mL vs. absence: 13 ng/mL, p < 0.0001, area under receiver operating characteristic curve (AUC) = 0.94; PTL-presence: 140 ng/mL vs. absence: 22 ng/mL, p < 0.0001, AUC = 0.86]. In cervical fluid, the concentrations of FcgammaBP were elevated in the presence of intra-amniotic infection in pregnancies with PPROM only (presence: 345 ng/mL vs. absence: 60 ng/mL, p < 0.0001, AUC = 0.93). FcgammaBP in amniotic fluid might be a marker of intra-amniotic infection in women with both PPROM and PTL However, in cervical fluid, it is only observed in women with PPROM.
650    _2
$a dospělí $7 D000328
650    _2
$a plodová voda $x metabolismus $7 D000653
650    _2
$a biologické markery $x metabolismus $7 D015415
650    _2
$a molekuly buněčné adheze $x metabolismus $7 D015815
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a těhotenství $7 D011247
650    _2
$a infekční komplikace v těhotenství $x metabolismus $7 D011251
650    _2
$a předčasný porod $x metabolismus $7 D047928
650    _2
$a retrospektivní studie $7 D012189
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kacerovsky, Marian $u The Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic. kacermar@fnhk.cz $u Biomedical Research Center, University Hospital Hradec Kralove, Hradec Králové, Czech Republic. kacermar@fnhk.cz
700    1_
$a Soucek, Ondrej $u Department of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Králové, Czech Republic
700    1_
$a Kolackova, Martina $u Department of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Králové, Czech Republic
700    1_
$a Musilova, Ivana $u The Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic
700    1_
$a Pliskova, Lenka $u Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Králové, Czech Republic
700    1_
$a Bolehovska, Radka $u Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Králové, Czech Republic
700    1_
$a Bostik, Pavel $u Institute of Clinical Microbiology, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Králové, Czech Republic
700    1_
$a Matulova, Jana $u Department of Social Medicine, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Králové, Czech Republic
700    1_
$a Jacobsson, Bo $u Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden $u Department of Obstetrics and Gynecology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden $u Department of Genetics and Bioinformatics, Domain of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway
700    1_
$a Andrys, Ctirad $u Department of Clinical Immunology and Allergy, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Králové, Czech Republic
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 11, č. 1 (2021), s. 6107
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33731725 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145152 $b ABA008
999    __
$a ok $b bmc $g 1751858 $s 1155677
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 11 $c 1 $d 6107 $e 20210317 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20220113
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace