Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients

J. Franeková, M. Protuš, E. Kieslichová, A. Březina, J. Komrsková, J. Vymětalík, A. Jabor

. 2021 ; 2021 (-) : 8831659. [pub] 20210105

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22004672

Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx < 2380 vs. non-Tx < 1368 ng/L, p < 0.05; procalcitonin: <28.0 vs. 3.49 μg/L, p < 0.05). In contrast, CRP and IL-6 were lower in the Tx group (CRP: Tx < 84.2 vs. non-Tx < 229 mg/L, p < 0.05; IL-6: <71.2 vs. 317 ng/L, p < 0.05). Decreases in CRP and IL-6 were found for all immunosuppressants, and procalcitonin was increased after antithymocyte globulin and corticosteroids. Negligible changes were found for white blood cells. Different responses of presepsin, procalcitonin, CRP, and IL-6 were therefore found in patients without any infectious complications after major surgery or transplantation. Immunosuppression decreased significantly IL-6 and CRP in comparison to non-Tx patients, while procalcitonin was increased after corticosteroids and antithymocyte globulin only. Cautious interpretation of sepsis biomarkers is needed in the early posttransplant period. This work was conducted as a noninterventional (nonregistered) study.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004672
003      
CZ-PrNML
005      
20220127145053.0
007      
ta
008      
220113s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2021/8831659 $2 doi
035    __
$a (PubMed)33505219
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Franeková, Janka $u Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic
245    10
$a Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients / $c J. Franeková, M. Protuš, E. Kieslichová, A. Březina, J. Komrsková, J. Vymětalík, A. Jabor
520    9_
$a Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx < 2380 vs. non-Tx < 1368 ng/L, p < 0.05; procalcitonin: <28.0 vs. 3.49 μg/L, p < 0.05). In contrast, CRP and IL-6 were lower in the Tx group (CRP: Tx < 84.2 vs. non-Tx < 229 mg/L, p < 0.05; IL-6: <71.2 vs. 317 ng/L, p < 0.05). Decreases in CRP and IL-6 were found for all immunosuppressants, and procalcitonin was increased after antithymocyte globulin and corticosteroids. Negligible changes were found for white blood cells. Different responses of presepsin, procalcitonin, CRP, and IL-6 were therefore found in patients without any infectious complications after major surgery or transplantation. Immunosuppression decreased significantly IL-6 and CRP in comparison to non-Tx patients, while procalcitonin was increased after corticosteroids and antithymocyte globulin only. Cautious interpretation of sepsis biomarkers is needed in the early posttransplant period. This work was conducted as a noninterventional (nonregistered) study.
650    _2
$a senioři $7 D000368
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a C-reaktivní protein $x metabolismus $7 D002097
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunosupresiva $x terapeutické užití $7 D007166
650    _2
$a interleukin-6 $x krev $7 D015850
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a sepse $x krev $7 D018805
655    _2
$a časopisecké články $7 D016428
700    1_
$a Protuš, Marek $u Department of Anesthesiology, Resuscitation, and Intensive Care, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic $u First Faculty of Medicine, Charles University, Kateřinská 1660/32, 121 08 Prague 2, Czech Republic
700    1_
$a Kieslichová, Eva $u Department of Anesthesiology, Resuscitation, and Intensive Care, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic $u First Faculty of Medicine, Charles University, Kateřinská 1660/32, 121 08 Prague 2, Czech Republic
700    1_
$a Březina, Aleš $u Department of Anesthesiology and Resuscitation, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic
700    1_
$a Komrsková, Jitka $u Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic
700    1_
$a Vymětalík, Jiří $u Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic
700    1_
$a Jabor, Antonín $u Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic
773    0_
$w MED00006378 $t Mediators of inflammation $x 1466-1861 $g Roč. 2021, č. - (2021), s. 8831659
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33505219 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145050 $b ABA008
999    __
$a ok $b bmc $g 1751977 $s 1155821
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 2021 $c - $d 8831659 $e 20210105 $i 1466-1861 $m Mediators of inflammation $n Mediators Inflamm $x MED00006378
LZP    __
$a Pubmed-20220113

Find record

Citation metrics

Archiving options