• Something wrong with this record ?

A new look at 9-substituted acridines with various biological activities

M. Kozurkova, D. Sabolova, P. Kristian

. 2021 ; 41 (1) : 175-189. [pub] 20200924

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc22004723

Heterocycles have long been the focus of intensive study in attempts to develop novel therapeutic compounds, and acridine, a polynuclear nitrogen molecule containing a heterocycle, has attracted a considerable amount of scientific attention. Acridine derivatives have been studied in detail and have been found to possess multitarget properties, which inhibit topoisomerase enzymes that regulate topological changes in DNA and interfere with the essential biological function of DNA. This article describes some recent advancements in the field of new 9-substituted acridine heterocyclic agents and describes both the structure and the structure-activity relationship of the most promising molecules. The article will also present the IC50 values of the novel derivatives against various human cancer cell lines. The mini review also investigates the topoisomerase inhibition and antibacterial and antimalarial activity of these polycyclic aromatic derivatives.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004723
003      
CZ-PrNML
005      
20220127145036.0
007      
ta
008      
220113s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1002/jat.4072 $2 doi
035    __
$a (PubMed)32969520
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Kozurkova, Maria $u Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University, Kosice, Slovak Republic $u Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
245    12
$a A new look at 9-substituted acridines with various biological activities / $c M. Kozurkova, D. Sabolova, P. Kristian
520    9_
$a Heterocycles have long been the focus of intensive study in attempts to develop novel therapeutic compounds, and acridine, a polynuclear nitrogen molecule containing a heterocycle, has attracted a considerable amount of scientific attention. Acridine derivatives have been studied in detail and have been found to possess multitarget properties, which inhibit topoisomerase enzymes that regulate topological changes in DNA and interfere with the essential biological function of DNA. This article describes some recent advancements in the field of new 9-substituted acridine heterocyclic agents and describes both the structure and the structure-activity relationship of the most promising molecules. The article will also present the IC50 values of the novel derivatives against various human cancer cell lines. The mini review also investigates the topoisomerase inhibition and antibacterial and antimalarial activity of these polycyclic aromatic derivatives.
650    _2
$a akridiny $x chemie $x farmakologie $x toxicita $7 D000166
650    _2
$a antibakteriální látky $x chemie $x farmakologie $x toxicita $7 D000900
650    _2
$a antimalarika $x chemie $x farmakologie $x toxicita $7 D000962
650    _2
$a protinádorové látky $x chemie $x farmakologie $x toxicita $7 D000970
650    _2
$a lidé $7 D006801
650    _2
$a vztahy mezi strukturou a aktivitou $7 D013329
650    _2
$a inhibitory topoisomerasy II $x chemie $x farmakologie $x toxicita $7 D059005
650    _2
$a nádorové buňky kultivované $x účinky léků $7 D014407
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Sabolova, Danica $u Department of Biochemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University, Kosice, Slovak Republic
700    1_
$a Kristian, Pavol $u Department of Organic Chemistry, Institute of Chemistry, Faculty of Science, P. J. Šafárik University, Kosice, Slovak Republic
773    0_
$w MED00008416 $t Journal of applied toxicology : JAT $x 1099-1263 $g Roč. 41, č. 1 (2021), s. 175-189
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32969520 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145032 $b ABA008
999    __
$a ok $b bmc $g 1752026 $s 1155872
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 41 $c 1 $d 175-189 $e 20200924 $i 1099-1263 $m JAT. Journal of applied toxicology $n J Appl Toxicol $x MED00008416
LZP    __
$a Pubmed-20220113
Back

Find record

Citation metrics

Archiving options