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A very rare case of possible actinomycosis of the mandible from the Middle Ages
L. Vargová, L. Horáčková, K. Vymazalová, A. Němečková, Z. Tvrdý, L. Galuška, J. Mitáček, D. Fialová
Language English Country Netherlands
Document type Case Reports, Historical Article, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Actinomycosis * diagnosis history pathology MeSH
- History, Medieval MeSH
- Adult MeSH
- Humans MeSH
- Mandible pathology MeSH
- Paleopathology MeSH
- Check Tag
- History, Medieval MeSH
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Historical Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
OBJECTIVE: Documented cases of actinomycosis in archaeological skeletons are very rare, especially from Central Europe. Our contribution will help facilitate the differential diagnosis of this disease for other paleopathologists. MATERIAL: This paper describes a pathological finding of the skeleton of a 40-year-old male from a burial ground in Sady-Špitálky (Czech Republic) dated to the 10th-12th century. METHODS: The affected skeleton was evaluated as a probable case of actinomycosis on the basis of a detailed macroscopic, X-ray and histological examination. The osteolytic foci examined were compared with similar changes caused by tuberculosis, syphilis and mycoses. RESULTS: The character and location of the defect on the mandible is indicative of organ actinomycosis and is also reflected by the lytic lesion observed on a lumbar vertebra. CONCLUSIONS: The described case can be considered one of the very rare paleopathological findings of possible actinomycosis in humans in Central Europe. SIGNIFICANCE: Good evidence of bone actinomycosis findings may be beneficial for further paleopathological and epidemiological studies, especially for research focused on the diachronic development of actinomycosis in Europe. In doing so, all available factors, such as hygiene habits, nutrition, social structure and overall health of the population that could be causally related to its origin, course and treatment, can be taken into account. LIMITATIONS: The mandible of the studied individual was damaged, especially in the area affected by the lesion, so the paleopathological analysis was difficult to perform. SUGGESTION FOR THE FUTURE RESEARCH: In future, actinomycosis in this skeleton may be confirmed by bio-molecular analysis.
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- $a Vargová, Lenka $u Division of Medical Anthropology, Department of Anatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czech Republic. Electronic address: vargova@med.muni.cz
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- $a A very rare case of possible actinomycosis of the mandible from the Middle Ages / $c L. Vargová, L. Horáčková, K. Vymazalová, A. Němečková, Z. Tvrdý, L. Galuška, J. Mitáček, D. Fialová
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- $a OBJECTIVE: Documented cases of actinomycosis in archaeological skeletons are very rare, especially from Central Europe. Our contribution will help facilitate the differential diagnosis of this disease for other paleopathologists. MATERIAL: This paper describes a pathological finding of the skeleton of a 40-year-old male from a burial ground in Sady-Špitálky (Czech Republic) dated to the 10th-12th century. METHODS: The affected skeleton was evaluated as a probable case of actinomycosis on the basis of a detailed macroscopic, X-ray and histological examination. The osteolytic foci examined were compared with similar changes caused by tuberculosis, syphilis and mycoses. RESULTS: The character and location of the defect on the mandible is indicative of organ actinomycosis and is also reflected by the lytic lesion observed on a lumbar vertebra. CONCLUSIONS: The described case can be considered one of the very rare paleopathological findings of possible actinomycosis in humans in Central Europe. SIGNIFICANCE: Good evidence of bone actinomycosis findings may be beneficial for further paleopathological and epidemiological studies, especially for research focused on the diachronic development of actinomycosis in Europe. In doing so, all available factors, such as hygiene habits, nutrition, social structure and overall health of the population that could be causally related to its origin, course and treatment, can be taken into account. LIMITATIONS: The mandible of the studied individual was damaged, especially in the area affected by the lesion, so the paleopathological analysis was difficult to perform. SUGGESTION FOR THE FUTURE RESEARCH: In future, actinomycosis in this skeleton may be confirmed by bio-molecular analysis.
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- $a Horáčková, Ladislava $u Division of Medical Sciences in Sports, Department of Kinesiology, Faculty of Sports Studies, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Electronic address: lhorac@fsps.muni.cz
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- $a Vymazalová, Kateřina $u Division of Medical Anthropology, Department of Anatomy, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czech Republic. Electronic address: vymazalova@med.muni.cz
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- $a Němečková, Alena $u Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Husova 3, 301 00, Pilsen, Czech Republic. Electronic address: alena.nemeckova@lfp.cuni.cz
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- $a Tvrdý, Zdeněk $u Anthropos Institute, Moravian Museum, Zelný trh 6, 659 37, Brno, Czech Republic. Electronic address: ztvrdy@mzm.cz
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- $a Galuška, Luděk $u Centre for Slavonic Archaeology, Moravian Museum, Velehradská třída 537, 686 01, Uherské Hradiště, Czech Republic. Electronic address: lgaluska@mzm.cz
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- $a Mitáček, Jiří $u Moravian Museum, Zelný trh 6, 659 37, Brno, Czech Republic. Electronic address: jmitacek@mzm.cz
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- $a Fialová, Dana $u Laboratory of Biological and Molecular Anthropology, Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. Electronic address: dfialova@sci.muni.cz
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