-
Something wrong with this record ?
Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex
R. Moavero, K. Kotulska, L. Lagae, A. Benvenuto, L. Emberti Gialloreti, B. Weschke, K. Riney, M. Feucht, P. Krsek, R. Nabbout, AC. Jansen, K. Wojdan, J. Borkowska, K. Sadowski, C. Hertzberg, MM. Van Schooneveld, S. Samueli, A. Maulisovà, E....
Language English Country United States
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2014
Free Medical Journals
from 2014 to 2 years ago
PubMed Central
from 2014
Europe PubMed Central
from 2014
ProQuest Central
from 2014-01-01
Open Access Digital Library
from 2014-01-01
Open Access Digital Library
from 2014-01-01
Health & Medicine (ProQuest)
from 2014-01-01
Psychology Database (ProQuest)
from 2014-01-01
Wiley-Blackwell Open Access Titles
from 2014
PubMed
32705817
DOI
10.1002/acn3.51128
Knihovny.cz E-resources
- MeSH
- Anticonvulsants administration & dosage MeSH
- Epilepsy complications drug therapy etiology MeSH
- Outcome Assessment, Health Care MeSH
- Infant MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Autism Spectrum Disorder etiology prevention & control MeSH
- Child, Preschool MeSH
- Tuberous Sclerosis complications MeSH
- Vigabatrin administration & dosage MeSH
- Developmental Disabilities etiology prevention & control MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
OBJECTIVE: To evaluate the relationship between age at seizure onset and neurodevelopmental outcome at age 24 months in infants with TSC, as well as the effect on neurodevelopmental outcome of early versus conventional treatment of epileptic seizures with vigabatrin (80-150 mg/kg/day). METHODS: Infants with TSC, aged ≤4 months and without previous seizures were enrolled in a prospective study and closely followed with monthly video EEG and serial standardized neurodevelopmental testing (Bayley Scales of Infant Development and Autism Diagnostic Observation Schedule). RESULTS: Eighty infants were enrolled. At the age of 24 months testing identified risk of Autism Spectrum Disorder (ASD) in 24/80 children (30.0%), and developmental delay (DD) in 26/80 (32.5%). Children with epilepsy (51/80; 63.8%) had a higher risk of ASD (P = 0.02) and DD (P = 0.001). Overall, no child presented with moderate or severe DD at 24 months (developmental quotient < 55). In 20% of children abnormal developmental trajectories were detected before the onset of seizures. Furthermore, 21% of all children with risk of ASD at 24 months had not developed seizures at that timepoint. There was no significant difference between early and conventional treatment with respect to rate of risk of ASD (P = 0.8) or DD (P = 0.9) at 24 months. INTERPRETATION: This study confirms a relationship between epilepsy and risk of ASD/DD. However, in this combined randomized/open label study, early treatment with vigabatrin did not alter the risk of ASD or DD at age 2 years.
Brigham and Women's Hospital Harvard Medical School Boston MA 02115
Department of Child Neurology Brain Center University Medical Center Utrecht Utrecht The Netherlands
Department of Child Neurology Medical University of Warsaw Warsaw Poland
Department of Pediatrics Medical University Vienna Vienna Austria
Diagnose und Behandlungszentrum für Kinder und Jugendliche Vivantes Klinikum Neuköln Berlin Germany
Pediatric Neurology Unit UZ Brussel Brussels Belgium
School of Clinical Medicine University of Queensland St Lucia QLD 4072 Australia
Stichting Epilepsie Instellingen Nederland Heemstede The Netherlands
Transition Technologies ul Pawia 5 Warsaw 01 030 Poland
Warsaw University of Technology Institute of Heat Engineering Warsaw Poland
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22004869
- 003
- CZ-PrNML
- 005
- 20220127144857.0
- 007
- ta
- 008
- 220113s2020 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1002/acn3.51128 $2 doi
- 035 __
- $a (PubMed)32705817
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Moavero, Romina $u Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Via Montpellier 1, Rome, 00133, Italy $u Child Neurology Unit, Neuroscience and Neurorehabilitation Department, "Bambino Gesù" Children's Hospital, IRCCS, P.zza S. Onofrio 4, Rome, 00165, Italy
- 245 10
- $a Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex / $c R. Moavero, K. Kotulska, L. Lagae, A. Benvenuto, L. Emberti Gialloreti, B. Weschke, K. Riney, M. Feucht, P. Krsek, R. Nabbout, AC. Jansen, K. Wojdan, J. Borkowska, K. Sadowski, C. Hertzberg, MM. Van Schooneveld, S. Samueli, A. Maulisovà, E. Aronica, DJ. Kwiatkowski, FE. Jansen, S. Jozwiak, P. Curatolo, EPISTOP Consortium
- 520 9_
- $a OBJECTIVE: To evaluate the relationship between age at seizure onset and neurodevelopmental outcome at age 24 months in infants with TSC, as well as the effect on neurodevelopmental outcome of early versus conventional treatment of epileptic seizures with vigabatrin (80-150 mg/kg/day). METHODS: Infants with TSC, aged ≤4 months and without previous seizures were enrolled in a prospective study and closely followed with monthly video EEG and serial standardized neurodevelopmental testing (Bayley Scales of Infant Development and Autism Diagnostic Observation Schedule). RESULTS: Eighty infants were enrolled. At the age of 24 months testing identified risk of Autism Spectrum Disorder (ASD) in 24/80 children (30.0%), and developmental delay (DD) in 26/80 (32.5%). Children with epilepsy (51/80; 63.8%) had a higher risk of ASD (P = 0.02) and DD (P = 0.001). Overall, no child presented with moderate or severe DD at 24 months (developmental quotient < 55). In 20% of children abnormal developmental trajectories were detected before the onset of seizures. Furthermore, 21% of all children with risk of ASD at 24 months had not developed seizures at that timepoint. There was no significant difference between early and conventional treatment with respect to rate of risk of ASD (P = 0.8) or DD (P = 0.9) at 24 months. INTERPRETATION: This study confirms a relationship between epilepsy and risk of ASD/DD. However, in this combined randomized/open label study, early treatment with vigabatrin did not alter the risk of ASD or DD at age 2 years.
- 650 _2
- $a antikonvulziva $x aplikace a dávkování $7 D000927
- 650 _2
- $a poruchy autistického spektra $x etiologie $x prevence a kontrola $7 D000067877
- 650 _2
- $a předškolní dítě $7 D002675
- 650 _2
- $a vývojové poruchy u dětí $x etiologie $x prevence a kontrola $7 D002658
- 650 _2
- $a epilepsie $x komplikace $x farmakoterapie $x etiologie $7 D004827
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kojenec $7 D007223
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a hodnocení výsledků zdravotní péče $7 D017063
- 650 _2
- $a tuberózní skleróza $x komplikace $7 D014402
- 650 _2
- $a vigabatrin $x aplikace a dávkování $7 D020888
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Kotulska, Katarzyna $u Department of Neurology and Epileptology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, 04-730, Poland
- 700 1_
- $a Lagae, Lieven $u Department of Development and Regeneration-Section Pediatric Neurology, University Hospitals KU Leuven, Leuven, Belgium
- 700 1_
- $a Benvenuto, Arianna $u Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Via Montpellier 1, Rome, 00133, Italy
- 700 1_
- $a Emberti Gialloreti, Leonardo $u Department of Biomedicine and Prevention, Tor Vergata University of Rome, Via Montpellier 1, Rome, 00133, Italy
- 700 1_
- $a Weschke, Bernhard $u Department of Child Neurology, Charité University Medicine Berlin, Augustenburger Platz 1, Berlin, 13353, Germany
- 700 1_
- $a Riney, Kate $u Neuroscience Unit, Queensland Children's Hospital, 501 Stanley Street, South Brisbane, QLD, 4101, Australia $u School of Clinical Medicine, University of Queensland, St Lucia, QLD, 4072, Australia
- 700 1_
- $a Feucht, Martha $u Department of Pediatrics, Medical University Vienna, Vienna, Austria
- 700 1_
- $a Krsek, Pavel $u Department of Paediatric Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
- 700 1_
- $a Nabbout, Rima $u Department of Pediatric Neurology, Reference Centre for Rare Epilepsies, Necker- Enfants Malades Hospital, University Paris Descartes, Imagine Institute, Paris, France
- 700 1_
- $a Jansen, Anna C $u Pediatric Neurology Unit-UZ Brussel, Brussels, Belgium
- 700 1_
- $a Wojdan, Konrad $u Warsaw University of Technology, Institute of Heat Engineering, Warsaw, Poland $u Transition Technologies, ul. Pawia 5, Warsaw, 01-030, Poland
- 700 1_
- $a Borkowska, Julita $u Department of Neurology and Epileptology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, 04-730, Poland
- 700 1_
- $a Sadowski, Krzysztof $u Department of Neurology and Epileptology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, 04-730, Poland
- 700 1_
- $a Hertzberg, Christoph $u Diagnose und Behandlungszentrum für Kinder und Jugendliche, Vivantes Klinikum Neuköln, Berlin, Germany
- 700 1_
- $a Van Schooneveld, Monique M $u Department of Child Neurology, Brain Center University Medical Center Utrecht, Utrecht, The Netherlands
- 700 1_
- $a Samueli, Sharon $u Department of Pediatrics, Medical University Vienna, Vienna, Austria
- 700 1_
- $a Maulisovà, Alice $u Department of Paediatric Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
- 700 1_
- $a Aronica, Eleonora $u Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, The Netherlands $u Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands
- 700 1_
- $a Kwiatkowski, David J $u Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115
- 700 1_
- $a Jansen, Floor E $u Department of Child Neurology, Brain Center University Medical Center Utrecht, Utrecht, The Netherlands
- 700 1_
- $a Jozwiak, Sergiusz $u Department of Neurology and Epileptology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, 04-730, Poland $u Department of Child Neurology, Medical University of Warsaw, Warsaw, Poland
- 700 1_
- $a Curatolo, Paolo $u Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, Via Montpellier 1, Rome, 00133, Italy
- 710 2_
- $a EPISTOP Consortium
- 773 0_
- $w MED00189500 $t Annals of clinical and translational neurology $x 2328-9503 $g Roč. 7, č. 8 (2020), s. 1371-1381
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32705817 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220113 $b ABA008
- 991 __
- $a 20220127144854 $b ABA008
- 999 __
- $a ok $b bmc $g 1752164 $s 1156018
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 7 $c 8 $d 1371-1381 $e 20200723 $i 2328-9503 $m Annals of clinical and translational neurology $n Ann Clin Transl Neurol $x MED00189500
- LZP __
- $a Pubmed-20220113
