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A simple neridronate-based surface coating strategy for upconversion nanoparticles: highly colloidally stable 125 I-radiolabeled NaYF 4:Yb 3+/Er 3+@PEG nanoparticles for multimodal in vivo tissue imaging
U Kostiv, V Lobaz, J Kucka, P Svec, O Sedlacek, M Hruby, O Janouskova, P Francova, V Kolarova, L Sefc, D Horak
Jazyk angličtina Země Velká Británie
Grantová podpora
NV16-30544A
MZ0
CEP - Centrální evidence projektů
PubMed
29067394
DOI
10.1039/c7nr05456d
Knihovny.cz E-zdroje
- MeSH
- bisfosfonáty * MeSH
- fluoridy MeSH
- HeLa buňky MeSH
- lidé MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- nanočástice * chemie MeSH
- radioizotopy jodu MeSH
- SPECT/CT * MeSH
- tkáňová distribuce MeSH
- ytrium MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
In this report, monodisperse upconversion NaYF4:Yb3+/Er3+ nanoparticles with superior optical properties were synthesized by the oleic acid-stabilized high-temperature co-precipitation of lanthanide chlorides in octadec-1-ene as a high-boiling organic solvent. To render the particles with biocompatibility and colloidal stability in bioanalytically relevant phosphate buffered saline (PBS), they were modified by using in-house synthesized poly(ethylene glycol)-neridronate (PEG-Ner), a bisphosponate. The NaYF4:Yb3+/Er3+@PEG nanoparticles showed excellent long-term stability in PBS and/or albumin without any aggregation or morphology transformation. The in vitro cytotoxicity of the nanoparticles was evaluated using primary fibroblasts (HF) and a cell line derived from human cervical carcinoma (HeLa). The particles were subsequently modified by using Bolton-Hunter-hydroxybisphosphonate to enable radiolabeling with 125I for single-photon emission computed tomography/computed tomography (SPECT/CT) bimodal imaging to monitor the biodistribution of the nanoparticles in non-tumor mice. The bimodal upconversion 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles are prospective for near-infrared (NIR) photothermal/photodynamic and SPECT/CT cancer theranostics.
Citace poskytuje Crossref.org
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