Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Annotation

general only: not a substitute for organ /metab or organ /chem; usually NIM; coordinate with substance /pharmacokin or /metab

DUI

D014018 MeSH Browser

CUI

M0021578

Previous indexing

Organ Specificity (1966-1977)

History note

78

Public note

78