• Something wrong with this record ?

Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis

M. Lunova, S. Frankova, H. Gottfriedova, R. Senkerikova, M. Neroldova, J. Kovac, E. Kieslichova, V. Lanska, E. Sticova, J. Spicak, M. Jirsa, J. Sperl

. 2021 ; 70 (4) : 563-577. [pub] 20210601

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22007910

Grant support
NV16-27546A MZ0 CEP Register

Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (HVPG). Our aim was to assess the contribution of liver fibrosis and portal hypertension to LS in patients with advanced liver cirrhosis. Eighty-one liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG and LS measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France). Liver collagen content was assessed in the explanted liver as collagen proportionate area (CPA) and hydroxyproline content (HP). The studied cohort included predominantly patients with Child-Pugh class B and C (63/81, 77.8%), minority of patients were Child-Pugh A (18/81, 22.2%). LS showed the best correlation with HVPG (r=0.719, p< 0.001), correlation of LS with CPA (r=0.441, p< 0.001) and HP/Amino Acids (r=0.414, p< 0.001) was weaker. Both variables expressing liver collagen content showed good correlation with each other (r=0.574, p<0.001). Multiple linear regression identified the strongest association between LS and HVPG (p < 0.0001) and weaker association of LS with CPA (p = 0.01883). Stepwise modelling showed minimal increase in r2 after addition of CPA to HVPG (0.5073 vs. 0.5513). The derived formula expressing LS value formation is: LS = 2.48 + (1.29 x HVPG) + (0.26 x CPA). We conclude that LS is determined predominantly by HVPG in patients with advanced liver cirrhosis whereas contribution of liver collagen content is relatively low.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc22007910
003      
CZ-PrNML
005      
20220323102116.0
007      
ta
008      
220309s2021 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934626 $2 doi
035    __
$a (PubMed)34062072
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Lunova, Mariia $7 _AN113480 $u Department of Hepatogastroenterology, Transplant Centre; Institute for Clinical and Experimental Medicine, Prague, Czech Republic
245    10
$a Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis / $c M. Lunova, S. Frankova, H. Gottfriedova, R. Senkerikova, M. Neroldova, J. Kovac, E. Kieslichova, V. Lanska, E. Sticova, J. Spicak, M. Jirsa, J. Sperl
504    __
$a Literatura
520    9_
$a Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (HVPG). Our aim was to assess the contribution of liver fibrosis and portal hypertension to LS in patients with advanced liver cirrhosis. Eighty-one liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG and LS measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France). Liver collagen content was assessed in the explanted liver as collagen proportionate area (CPA) and hydroxyproline content (HP). The studied cohort included predominantly patients with Child-Pugh class B and C (63/81, 77.8%), minority of patients were Child-Pugh A (18/81, 22.2%). LS showed the best correlation with HVPG (r=0.719, p< 0.001), correlation of LS with CPA (r=0.441, p< 0.001) and HP/Amino Acids (r=0.414, p< 0.001) was weaker. Both variables expressing liver collagen content showed good correlation with each other (r=0.574, p<0.001). Multiple linear regression identified the strongest association between LS and HVPG (p < 0.0001) and weaker association of LS with CPA (p = 0.01883). Stepwise modelling showed minimal increase in r2 after addition of CPA to HVPG (0.5073 vs. 0.5513). The derived formula expressing LS value formation is: LS = 2.48 + (1.29 x HVPG) + (0.26 x CPA). We conclude that LS is determined predominantly by HVPG in patients with advanced liver cirrhosis whereas contribution of liver collagen content is relatively low.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a kolagen $x analýza $7 D003094
650    _2
$a elastografie $7 D054459
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a portální hypertenze $x diagnóza $x patofyziologie $x chirurgie $7 D006975
650    _2
$a játra $x chemie $x diagnostické zobrazování $x patologie $x chirurgie $7 D008099
650    _2
$a jaterní cirhóza $x metabolismus $x patologie $x patofyziologie $x chirurgie $7 D008103
650    _2
$a transplantace jater $7 D016031
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    12
$a portální tlak $7 D017082
650    _2
$a prediktivní hodnota testů $7 D011237
650    _2
$a prospektivní studie $7 D011446
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Fraňková, Soňa $7 xx0329475 $u Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Gottfriedová, Halima $7 xx0077274 $u Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Šenkeříková, Renáta $7 xx0220134 $u Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Neřoldová, Magdaléna $7 xx0235816 $u Department of Hepatogastroenterology, Transplant Centre; Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Kováč, Jozef, $d 1950- $7 xx0108366 $u Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Kieslichová, Eva $7 xx0143519 $u Anesthesiology, Resuscitation and Intensive Care Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Lánská, Věra $7 xx0062305 $u Department of Biostatistics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Sticová, Eva $7 xx0108073 $u Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Špičák, Julius, $d 1952- $7 jn20000919536 $u Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Jirsa, Milan, $d 1959- $7 xx0068937 $u Laboratory of Experimental Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Šperl, Jan $7 xx0071614 $u Laboratory of Experimental Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic $u Department of Internal Medicine, 1st Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 70, č. 4 (2021), s. 563-577
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34062072 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20220309 $b ABA008
991    __
$a 20220323102111 $b ABA008
999    __
$a ok $b bmc $g 1773040 $s 1159103
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 70 $c 4 $d 563-577 $e 20210601 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NV16-27546A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20220309

Find record

Citation metrics

Archiving options