• Je něco špatně v tomto záznamu ?

COVID-19, oxidative stress, and male reproductive dysfunctions: is vitamin C a potential remedy

P. Sengupta, S. Dutta, P. Slama, S. Roychoudhury

. 2022 ; 71 (1) : 47-54. [pub] 20220119

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22009479

Few peculiarities have been observed in the etiology of coronavirus disease 2019 (COVID-19), one such being its greater prevalence in men than women partly due to the higher expressions of angiotensin-converting enzyme-2 (ACE2) in the male reproductive tissues. Recent scientific reports are in line with some of the evidence-based hypotheses in the initial phase of the COVID-19 pandemic, regarding the involvement of oxidative stress (OS) and oxidant-sensitive pathways in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-mediated male reproductive disruptions. The seminal dissemination of SARS-CoV-2 or its components, testicular disruptions due to viral infection and oxidative damage in the testis have all been evidenced recently. High-dose of antioxidants, such as vitamin C, have been shown to be a useful treatment for COVID-19 patients, to alleviate systemic inflammation and OS. In addition, vitamin C is a major testicular antioxidant that neutralizes excess reactive oxygen species (ROS), prevents sperm agglutination, prevents lipid peroxidation, recycles vitamin E, and protects against DNA damage. Thus, the present review aims to discuss the mechanism of COVID-19-mediated male reproductive dysfunctions, based on the evidence available so far, and explore the possibility of using vitamin C in alleviating testicular OS and associated damage caused by COVID-19.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22009479
003      
CZ-PrNML
005      
20230331092843.0
007      
ta
008      
220419s2022 xr a f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934827 $2 doi
035    __
$a (PubMed)35043653
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Sengupta, Pallav $u Faculty of Medicine, Bioscience and Nursing, Malaysian Allied Health Sciences Academy, Jenjarom, Malaysia $u School of Medical Sciences, Bharath Institute of Health Sciences and Research, Chennai, India
245    10
$a COVID-19, oxidative stress, and male reproductive dysfunctions: is vitamin C a potential remedy / $c P. Sengupta, S. Dutta, P. Slama, S. Roychoudhury
520    9_
$a Few peculiarities have been observed in the etiology of coronavirus disease 2019 (COVID-19), one such being its greater prevalence in men than women partly due to the higher expressions of angiotensin-converting enzyme-2 (ACE2) in the male reproductive tissues. Recent scientific reports are in line with some of the evidence-based hypotheses in the initial phase of the COVID-19 pandemic, regarding the involvement of oxidative stress (OS) and oxidant-sensitive pathways in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-mediated male reproductive disruptions. The seminal dissemination of SARS-CoV-2 or its components, testicular disruptions due to viral infection and oxidative damage in the testis have all been evidenced recently. High-dose of antioxidants, such as vitamin C, have been shown to be a useful treatment for COVID-19 patients, to alleviate systemic inflammation and OS. In addition, vitamin C is a major testicular antioxidant that neutralizes excess reactive oxygen species (ROS), prevents sperm agglutination, prevents lipid peroxidation, recycles vitamin E, and protects against DNA damage. Thus, the present review aims to discuss the mechanism of COVID-19-mediated male reproductive dysfunctions, based on the evidence available so far, and explore the possibility of using vitamin C in alleviating testicular OS and associated damage caused by COVID-19.
650    _2
$a kyselina askorbová $x terapeutické užití $7 D001205
650    12
$a COVID-19 $7 D000086382
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a oxidační stres $7 D018384
650    _2
$a pandemie $7 D058873
650    _2
$a SARS-CoV-2 $7 D000086402
650    _2
$a farmakoterapie COVID-19 $7 D000093485
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Dutta, Sulagna $u School of Medical Sciences, Bharath Institute of Health Sciences and Research, Chennai, India $u Faculty of Dentistry, Malaysian Allied Health Sciences Academy, Jenjarom, Malaysia
700    1_
$a Sláma, Petr, $d 1979- $7 stk2007383506 $u Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic
700    1_
$a Roychoudhury, Shubhadeep $u Department of Life Science and Bioinformatics, Assam University, Silchar, India
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 71, č. 1 (2022), s. 47-54
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35043653 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20220419 $b ABA008
991    __
$a 20230331092838 $b ABA008
999    __
$a ok $b bmc $g 1796987 $s 1160677
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 71 $c 1 $d 47-54 $e 20220119 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK198 $a Pubmed-20220419

Najít záznam

Citační ukazatele

Možnosti archivace