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Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat
M. Pravenec, J. Šilhavý, P. Mlejnek, M. Šimáková, T. Mráček, A. Pecinová, K. Tauchmannová, M. Hütl, H. Malínská, L. Kazdová, J. Neckář, F. Kolář, J. Žurmanová, J. Novotný, J. Houštěk
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Free Medical Journals od 1998
PubMed Central od 2020
ProQuest Central od 2005-01-01
Medline Complete (EBSCOhost) od 2006-01-01
Nursing & Allied Health Database (ProQuest) od 2005-01-01
Health & Medicine (ProQuest) od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources od 1998
Odkazy
PubMed
35199537
DOI
10.33549/physiolres.934740
Knihovny.cz E-zdroje
- MeSH
- fenotyp MeSH
- kardiovaskulární nemoci * metabolismus MeSH
- krysa rodu rattus MeSH
- mitochondriální DNA * genetika MeSH
- mitochondrie metabolismus MeSH
- potkani inbrední F344 MeSH
- potkani inbrední SHR MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus. Recently, natural mitochondrial genome (mtDNA) polymorphisms (haplogroups) received increasing attention in the pathophysiology of human common diseases. However, retrograde effects of mtDNA variants on such traits are difficult to study in humans. The conplastic strains represent key animal models to elucidate regulatory roles of mtDNA haplogroups on defined nuclear genome background. To analyze the relationship between mtDNA variants and cardiometabolic traits, we derived a set of rat conplastic strains (SHR-mtBN, SHR-mtF344 and SHR-mtLEW), harboring all major mtDNA haplotypes present in common inbred strains on the nuclear background of the spontaneously hypertensive rat (SHR). The BN, F344 and LEW mtDNA differ from the SHR in multiple amino acid substitutions in protein coding genes and also in variants of tRNA and rRNA genes. Different mtDNA haplotypes were found to predispose to various sets of cardiometabolic phenotypes which provided evidence for significant retrograde effects of mtDNA in the SHR. In the future, these animals could be used to decipher individual biochemical components involved in the retrograde signaling.
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