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Early-stage visual perception impairment in schizophrenia, bottom-up and back again

P. Adámek, V. Langová, J. Horáček

. 2022 ; 8 (1) : 27. [pub] 20220321

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22009758

Grantová podpora
1070119 Grantová Agentura, Univerzita Karlova (Charles University Grant Agency)
1070119 Grantová Agentura, Univerzita Karlova (Charles University Grant Agency)
1070119 Grantová Agentura, Univerzita Karlova (Charles University Grant Agency)

Visual perception is one of the basic tools for exploring the world. However, in schizophrenia, this modality is disrupted. So far, there has been no clear answer as to whether the disruption occurs primarily within the brain or in the precortical areas of visual perception (the retina, visual pathways, and lateral geniculate nucleus [LGN]). A web-based comprehensive search of peer-reviewed journals was conducted based on various keyword combinations including schizophrenia, saliency, visual cognition, visual pathways, retina, and LGN. Articles were chosen with respect to topic relevance. Searched databases included Google Scholar, PubMed, and Web of Science. This review describes the precortical circuit and the key changes in biochemistry and pathophysiology that affect the creation and characteristics of the retinal signal as well as its subsequent modulation and processing in other parts of this circuit. Changes in the characteristics of the signal and the misinterpretation of visual stimuli associated with them may, as a result, contribute to the development of schizophrenic disease.

Citace poskytuje Crossref.org

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