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Different FreeSurfer versions might generate different statistical outcomes in case-control comparison studies
P. Filip, P. Bednarik, LE. Eberly, A. Moheet, A. Svatkova, H. Grohn, AF. Kumar, ER. Seaquist, S. Mangia
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
Grantová podpora
P41 EB027061
NIBIB NIH HHS - United States
R01DK099137
NIH HHS - United States
UL1TR000114
NIH HHS - United States
P30 NS076408
NINDS NIH HHS - United States
P30 NS076408
NIH HHS - United States
P41 EB015894
NIH HHS - United States
KL2TR000113
NIH HHS - United States
R56 DK099137
NIDDK NIH HHS - United States
P41 EB015894
NIBIB NIH HHS - United States
P41 EB027061
NIH HHS - United States
R01 DK099137
NIDDK NIH HHS - United States
R56DK099137
NIH HHS - United States
UL1 TR000114
NCATS NIH HHS - United States
KL2 TR000113
NCATS NIH HHS - United States
NLK
ProQuest Central
od 2002-01-01 do Před 1 rokem
CINAHL Plus with Full Text (EBSCOhost)
od 2008-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2003-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2002-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2002-01-01 do Před 1 rokem
- MeSH
- lidé MeSH
- magnetická rezonanční tomografie * metody MeSH
- mozek diagnostické zobrazování patologie MeSH
- neurozobrazování * metody MeSH
- počítačové zpracování obrazu MeSH
- software MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
PURPOSE: Neuroimaging pipelines have long been known to generate mildly differing results depending on various factors, including software version. While considered generally acceptable and within the margin of reasonable error, little is known about their effect in common research scenarios such as inter-group comparisons between healthy controls and various pathological conditions. The aim of the presented study was to explore the differences in the inferences and statistical significances in a model situation comparing volumetric parameters between healthy controls and type 1 diabetes patients using various FreeSurfer versions. METHODS: T1- and T2-weighted structural scans of healthy controls and type 1 diabetes patients were processed with FreeSurfer 5.3, FreeSurfer 5.3 HCP, FreeSurfer 6.0 and FreeSurfer 7.1, followed by inter-group statistical comparison using outputs of individual FreeSurfer versions. RESULTS: Worryingly, FreeSurfer 5.3 detected both cortical and subcortical volume differences out of the preselected regions of interest, but newer versions such as FreeSurfer 5.3 HCP and FreeSurfer 6.0 reported only subcortical differences of lower magnitude and FreeSurfer 7.1 failed to find any statistically significant inter-group differences. CONCLUSION: Since group averages of individual FreeSurfer versions closely matched, in keeping with previous literature, the main origin of this disparity seemed to lie in substantially higher within-group variability in the model pathological condition. Ergo, until validation in common research scenarios as case-control comparison studies is included into the development process of new software suites, confirmatory analyses utilising a similar software based on analogous, but not fully equivalent principles, might be considered as supplement to careful quality control.
Department of Imaging Methods Faculty of Medicine University of Ostrava Ostrava Czechia
Department of Medicine University of Minnesota Minneapolis MN USA
Diagnostic Imaging Center Kuopio University Hospital Kuopio Finland
Division of Biostatistics School of Public Health University of Minnesota Minnesota MN USA
Citace poskytuje Crossref.org
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