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High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19
M. De Zuani, P. Lazničková, V. Tomašková, M. Dvončová, G. Forte, GB. Stokin, V. Šrámek, M. Helán, J. Frič
Language English Country Great Britain
Document type Journal Article, Observational Study
Grant support
CZ.02.1.01/0.0/0.0/15_003/0000492
European Social Fund and European Regional Development Fund-Project MAGNET
CZ.02.1.01/0.0/0.0/16_019/0000868
ENOCH
NV18-06-00529
Ministry of Health of the Czech Republic
NU21J-05-00056
Ministry of Health of the Czech Republic
00023736
DRO (Institute of Hematology and Blood Transfusion - UHKT)
European Regional Development Fund - Project
CZ.02.2.69/0.0/0.0/19_074/0016274
FNUSA-ICRC
NLK
Free Medical Journals
from 1997 to 1 year ago
Medline Complete (EBSCOhost)
from 1972-01-01 to 1 year ago
Wiley Free Content
from 1997 to 1 year ago
PubMed
34861051
DOI
10.1111/sji.13125
Knihovny.cz E-resources
- MeSH
- CD4-Positive T-Lymphocytes immunology MeSH
- CD8-Positive T-Lymphocytes immunology MeSH
- COVID-19 immunology MeSH
- Immunophenotyping methods MeSH
- Intensive Care Units MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphocyte Count methods MeSH
- CD4-CD8 Ratio methods MeSH
- Prospective Studies MeSH
- SARS-CoV-2 immunology MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
Celica BIOMEDICAL Ljubljana Slovenia
Department of Biology Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Hematology and Blood Transfusion Prague Czech Republic
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
References provided by Crossref.org
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