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The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy
B. Belhassen, M. Laredo, RW. Roudijk, G. Peretto, G. Zahavi, S. Sen-Chowdhry, N. Badenco, ASJM. Te Riele, S. Sala, G. Duthoit, JP. van Tintelen, G. Paglino, JM. Sellal, A. Gasperetti, E. Arbelo, A. Andorin, S. Ninni, A. Rollin, P. Peichl, X....
Language English Country Great Britain
Document type Journal Article
NLK
Free Medical Journals
from 1999 to 1 year ago
PubMed Central
from 2008
Open Access Digital Library
from 1999-01-01
Medline Complete (EBSCOhost)
from 1999-01-01
Oxford Journals Open Access Collection
from 1999-01-01
- MeSH
- Bundle-Branch Block diagnosis epidemiology therapy MeSH
- Electrocardiography MeSH
- Cardiomyopathies * complications epidemiology genetics MeSH
- Tachycardia, Ventricular * diagnosis epidemiology genetics MeSH
- Humans MeSH
- Prevalence MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
AIMS: In arrhythmogenic cardiomyopathy (ACM), sustained ventricular tachycardia (VT) typically displays a left bundle branch block (LBBB) morphology while a right bundle branch block (RBBB) morphology is rare. The present study assesses the VT morphology in ACM patients with sustained VT and their clinical and genetic characteristics. METHODS AND RESULTS: Twenty-six centres from 11 European countries provided information on 954 ACM patients who had ≥1 episode of sustained VT spontaneously documented during patients' clinical course. Arrhythmogenic cardiomyopathy was defined according to the 2010 Task Force Criteria, and VT morphology according to the QRS pattern in V1. Overall, 882 (92.5%) patients displayed LBBB-VT alone and 72 (7.5%) RBBB-VT [alone in 42 (4.4%) or in combination with LBBB-VT in 30 (3.1%)]. Male sex prevalence was 79.3%, 88.1%, and 56.7% in the LBBB-VT, RBBB-VT, and LBBB + RBBB-VT groups, respectively (P = 0.007). First RBBB-VT occurred 5 years after the first LBBB-VT (46.5 ± 14.4 vs 41.1 ± 15.8 years, P = 0.011). An implanted cardioverter-defibrillator was more frequently implanted in the RBBB-VT (92.9%) and the LBBB + RBBB-VT groups (90%) than in the LBBB-VT group (68.1%) (P < 0.001). Mutations in PKP2 predominated in the LBBB-VT (65.2%) and the LBBB + RBBB-VT (41.7%) groups while DSP mutations predominated in the RBBB-VT group (45.5%). By multivariable analysis, female sex was associated with LBBB + RBBB-VT (P = 0.011) while DSP mutations were associated with RBBB-VT (P < 0.001). After a median follow-up of 103 (51-185) months, death occurred in 106 (11.1%) patients with no intergroup difference (P = 0.176). CONCLUSION: RBBB-VT accounts for a significant proportion of sustained VTs in ACM. Sex and type of pathogenic mutations were associated with VT type, female sex with LBBB + RBBB-VT, and DSP mutation with RBBB-VT.
Cardiology University Hospital Rangueil 1 Avenue du Professeur Jean Poulhès 31400 Toulouse France
Centre Hospitalier Universitaire d'Amiens Picardie 2 Place Victor Pauchet 80080 Amiens France
Department of Anesthesiology Sheba Medical Center Tel Hashomer 5265601 Israel
Department of Cardiology University Medical Center 62 Huntley St London WC1E 6DD The Netherlands
Department of Genetics University Medical Center Moreelsepark 1 3511 EP Utrecht The Netherlands
Division of Cardiology Policlinico Casilino Via Casilina 1049 00169 Roma RM Italy
Heart Institute Hadassah University Hospital Kalman Ya'Akov Man Street 9112001 Jerusalem Israel
Institute of Cardiovascular Science University College London 62 Huntley St London WC1E 6DD UK
IRCCS San Raffaele Scientific Institute Via Olgettina 60 20132 Milano Italy
Leviev Heart Institute Sheba Medical Center 5265601 Tel Hashomer Israel
Netherlands Heart Institute Moreelsepark 1 3511 EP Utrecht The Netherlands
Nikos Protonotarios Medical Centre Περιφερειακός 843 00 Naxos Greece
Sackler School of Medicine Tel Aviv University P O Box 39040 Tel Aviv 6997801 Israel
Service de Cardiologie CHU de Nantes Bd Jacques Monod 44800 Saint Herblain Nantes France
UCL Institute of Cardiovascular Science 62 Huntley St London WC1E 6DD UK
Université François Rabelais 60 rue du Plat D'Etain 37020 Tours cedex 1 France
References provided by Crossref.org
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- $a The prevalence of left and right bundle branch block morphology ventricular tachycardia amongst patients with arrhythmogenic cardiomyopathy and sustained ventricular tachycardia: insights from the European Survey on Arrhythmogenic Cardiomyopathy / $c B. Belhassen, M. Laredo, RW. Roudijk, G. Peretto, G. Zahavi, S. Sen-Chowdhry, N. Badenco, ASJM. Te Riele, S. Sala, G. Duthoit, JP. van Tintelen, G. Paglino, JM. Sellal, A. Gasperetti, E. Arbelo, A. Andorin, S. Ninni, A. Rollin, P. Peichl, X. Waintraub, LP. Bosman, B. Pierre, E. Nof, C. Miles, J. Tfelt-Hansen, A. Protonotarios, C. Giustetto, F. Sacher, JS. Hermida, S. Havranek, L. Calo, R. Casado-Arroyo, G. Conte, KP. Letsas, E. Zorio, FJ. Bermúdez-Jiménez, ER. Behr, R. Beinart, L. Fauchier, J. Kautzner, P. Maury, D. Lacroix, V. Probst, J. Brugada, F. Duru, C. de Chillou, PD. Bella, E. Gandjbakhch, R. Hauer, A. Milman
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