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Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts

K. Strnadová, L. Pfeiferová, P. Přikryl, B. Dvořánková, E. Vlčák, J. Frýdlová, M. Vokurka, J. Novotný, J. Šáchová, M. Hradilová, J. Brábek, J. Šmigová, D. Rösel, K. Smetana, M. Kolář, L. Lacina

. 2022 ; 157 (2) : 153-172. [pub] 20211127

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22011151

Grantová podpora
No. 19-05048S Czech Science Foundation project
project CZ.02.1.01/0.0/0.0/16_019/0000785 "Centre for Tumour Ecology-Research of the Cancer Microenvironment Supporting Cancer Growth Spread" Operational Programme "Research, Development and Education"
PROGRESS Q28 Univerzita Karlova v Praze
CZ.02.1.01/0.0/0.0/16_013/0001775 ERDF
CZ.02.1.01/0.0/0.0/18_046/0016045 ERDF
LM2018129 MEYS

E-zdroje Online Plný text

NLK ProQuest Central od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2000-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 1997-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1997-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 1997-01-01 do Před 1 rokem

Odkazy

PubMed 34837514
DOI 10.1007/s00418-021-02052-2
Knihovny.cz E-zdroje

The incidence of cutaneous malignant melanoma is increasing worldwide. While the treatment of initial stages of the disease is simple, the advanced disease frequently remains fatal despite novel therapeutic options . This requires identification of novel therapeutic targets in melanoma. Similarly to other types of tumours, the cancer microenvironment plays a prominent role and determines the biological properties of melanoma. Importantly, melanoma cell-produced exosomes represent an important tool of intercellular communication within this cancer ecosystem. We have focused on potential differences in the activity of exosomes produced by melanoma cells towards melanoma-associated fibroblasts and normal dermal fibroblasts. Cancer-associated fibroblasts were activated by the melanoma cell-produced exosomes significantly more than their normal counterparts, as assessed by increased transcription of genes for inflammation-supporting cytokines and chemokines, namely IL-6 or IL-8. We have observed that the response is dependent on the duration of the stimulus via exosomes and also on the quantity of exosomes. Our study demonstrates that melanoma-produced exosomes significantly stimulate the tumour-promoting proinflammatory activity of cancer-associated fibroblasts. This may represent a potential new target of oncologic therapy .

Citace poskytuje Crossref.org

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