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MRI Characteristics of Pediatric Renal Tumors: A SIOP-RTSG Radiology Panel Delphi Study
JN. van der Beek, TA. Watson, RAJ. Nievelstein, HJ. Brisse, C. Morosi, HM. Lederman, A. Coma, MM. Gavra, K. Vult von Steyern, K. Lakatos, L. Breysem, E. Varga, H. Ducou Le Pointe, MH. Lequin, JF. Schäfer, HJ. Mentzel, AM. Hötker, G. Calareso, S....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
34363274
DOI
10.1002/jmri.27878
Knihovny.cz E-zdroje
- MeSH
- delfská metoda MeSH
- difuzní magnetická rezonance MeSH
- lidé MeSH
- nádory ledvin * diagnostické zobrazování MeSH
- radiologie * MeSH
- Wilmsův nádor * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: The SIOP-Renal Tumor Study Group (RTSG) does not advocate invasive procedures to determine histology before the start of therapy. This may induce misdiagnosis-based treatment initiation, but only for a relatively small percentage of approximately 10% of non-Wilms tumors (non-WTs). MRI could be useful for reducing misdiagnosis, but there is no global consensus on differentiating characteristics. PURPOSE: To identify MRI characteristics that may be used for discrimination of newly diagnosed pediatric renal tumors. STUDY TYPE: Consensus process using a Delphi method. POPULATION: Not applicable. FIELD STRENGTH/SEQUENCE: Abdominal MRI including T1- and T2-weighted imaging, contrast-enhanced MRI, and diffusion-weighted imaging at 1.5 or 3 T. ASSESSMENT: Twenty-three radiologists from the SIOP-RTSG radiology panel with ≥5 years of experience in MRI of pediatric renal tumors and/or who had assessed ≥50 MRI scans of pediatric renal tumors in the past 5 years identified potentially discriminatory characteristics in the first questionnaire. These characteristics were scored in the subsequent second round, consisting of 5-point Likert scales, ranking- and multiple choice questions. STATISTICAL TESTS: The cut-off value for consensus and agreement among the majority was ≥75% and ≥60%, respectively, with a median of ≥4 on the Likert scale. RESULTS: Consensus on specific characteristics mainly concerned the discrimination between WTs and non-WTs, and WTs and nephrogenic rest(s) (NR)/nephroblastomatosis. The presence of bilateral lesions (75.0%) and NR/nephroblastomatosis (65.0%) were MRI characteristics indicated as specific for the diagnosis of a WT, and 91.3% of the participants agreed that MRI is useful to distinguish NR/nephroblastomatosis from WT. Furthermore, all participants agreed that age influenced their prediction in the discrimination of pediatric renal tumors. DATA CONCLUSION: Although the discrimination of pediatric renal tumors based on MRI remains challenging, this study identified some specific characteristics for tumor subtypes, based on the shared opinion of experts. These results may guide future validation studies and innovative efforts. LEVEL OF EVIDENCE: 3 Technical Efficacy Stage: 3.
Center for Medical Imaging and Physiology Skåne University Hospital Lund University Lund Sweden
Department of Diagnostic Imaging Escola Paulista de Medicina UNIFESP São Paulo Brazil
Department of Paediatric Radiology Great Ormond Street Hospital NHS Foundation Trust London UK
Department of Paediatric Radiology Leeds Teaching Hospitals Leeds UK
Department of Pathology University Medical Center Utrecht Utrecht The Netherlands
Department of Pediatric Imaging Hôpital d'Enfants Armand Trousseau APHP Paris France
Department of Pediatric Radiology Hospital Vall d'Hebron Barcelona Spain
Department of Pediatrics Semmelweis University Budapest Hungary
Department of Radiology Bambino Gesù Children's Hospital Rome Italy
Department of Radiology Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy
Department of Radiology University Hospitals Leuven Leuven Belgium
Imaging Department Institut Curie Paris France
Institute of Diagnostic and Interventional Radiology University Hospital Zurich Zurich Switzerland
Princess Máxima Center for Pediatric Oncology Utrecht The Netherlands
Radiology Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy
Citace poskytuje Crossref.org
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