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The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises

Á. Ortega, I. Vera, MP. Diaz, C. Navarro, M. Rojas, W. Torres, H. Parra, J. Salazar, JB. De Sanctis, V. Bermúdez

. 2021 ; 23 (1) : . [pub] 20211231

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22011608

Grantová podpora
CZ.02.1.01/0.0/0.0/16_019/0000868 European Structural and Investment Operational Funds Program Research entitled: Molecular, cellular, and clinical approach to healthy ageing grant ENOCH
CC-0437-10-21-09-10 Consejo de Desarrollo Científico, Humanístico y Tecnológico, Universidad del Zulia

The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways' role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.

Citace poskytuje Crossref.org

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