Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins

AY. Kostygov, D. Grybchuk, Y. Kleschenko, DS. Chistyakov, AN. Lukashev, ES. Gerasimov, V. Yurchenko

. 2021 ; 13 (11) : . [pub] 20211119

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22011913

Leishmania spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of Leishmania RNA virus (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera Viannia and Leishmania, respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in L. major) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22011913
003      
CZ-PrNML
005      
20250610112053.0
007      
ta
008      
220425s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/v13112305 $2 doi
035    __
$a (PubMed)34835111
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Kostygov, Alexei Yu $u Life Science Research Centre, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic $u Zoological Institute of the Russian Academy of Sciences, 199034 St. Petersburg, Russia $1 https://orcid.org/000000021516437X $7 xx0332796
245    10
$a Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins / $c AY. Kostygov, D. Grybchuk, Y. Kleschenko, DS. Chistyakov, AN. Lukashev, ES. Gerasimov, V. Yurchenko
520    9_
$a Leishmania spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of Leishmania RNA virus (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera Viannia and Leishmania, respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in L. major) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.
650    _2
$a zvířata $7 D000818
650    _2
$a virové plášťové proteiny $x genetika $7 D036022
650    _2
$a lidé $7 D006801
650    _2
$a Leishmania $x virologie $7 D007891
650    _2
$a leishmanióza $x virologie $7 D007896
650    _2
$a RNA-viry $x genetika $7 D012328
650    _2
$a RNA virová $x analýza $7 D012367
650    _2
$a RNA-dependentní RNA-polymerasa $x genetika $7 D012324
650    _2
$a virové proteiny $x genetika $7 D014764
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Grybchuk, Danyil $u Life Science Research Centre, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic $u Central European Institute of Technology, Masaryk University, 60177 Brno, Czech Republic
700    1_
$a Kleschenko, Yulia $u Martsinovsky Institute of Medical Parasitology, Sechenov University, 119435 Moscow, Russia
700    1_
$a Chistyakov, Daniil S $u Martsinovsky Institute of Medical Parasitology, Sechenov University, 119435 Moscow, Russia $u Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia
700    1_
$a Lukashev, Alexander N $u Martsinovsky Institute of Medical Parasitology, Sechenov University, 119435 Moscow, Russia
700    1_
$a Gerasimov, Evgeny S $u Faculty of Biology, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia $u Institute for Information Transmission Problems, Russian Academy of Sciences, 127051 Moscow, Russia $1 https://orcid.org/0000000204971221
700    1_
$a Yurchenko, Vyacheslav $u Life Science Research Centre, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic $u Martsinovsky Institute of Medical Parasitology, Sechenov University, 119435 Moscow, Russia $1 https://orcid.org/0000000347653263 $7 xx0234303
773    0_
$w MED00177099 $t Viruses $x 1999-4915 $g Roč. 13, č. 11 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34835111 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20250610112046 $b ABA008
999    __
$a ok $b bmc $g 1789490 $s 1163114
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 13 $c 11 $e 20211119 $i 1999-4915 $m Viruses $n Viruses $x MED00177099
LZP    __
$a Pubmed-20220425

Najít záznam

Citační ukazatele

Možnosti archivace